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Bipolar affective disorder. I. Comprehensive quantitative computed tomography.

M J Dewan1, C V Haldipur, E E Lane

  • 1Department of Psychiatry, S.U.N.Y. Health Science Center.

Acta Psychiatrica Scandinavica
|June 1, 1988
PubMed
Summary
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Bipolar disorder patients show enlarged third ventricles and increased brain density in specific areas compared to controls. These findings suggest distinct structural brain abnormalities in bipolar disorder, potentially impacting its causes.

Area of Science:

  • Neuroscience
  • Psychiatry
  • Radiology

Background:

  • Bipolar disorder shares clinical symptoms with schizophrenia.
  • Previous computed tomography (CT) studies indicate structural brain abnormalities in bipolar patients.

Purpose of the Study:

  • To quantitatively evaluate brain structure in bipolar disorder patients using CT.
  • To compare ventricular and sulcal size, and cerebral parenchymal density between bipolar patients and controls.

Main Methods:

  • Computed tomography (CT) scans were performed on 26 DSM-III bipolar patients and 22 healthy controls.
  • Quantitative measures of third ventricle size, sulcal size, and cerebral parenchymal density were analyzed.

Main Results:

  • Bipolar patients exhibited significantly increased third ventricle size compared to controls.

Related Experiment Videos

  • Increased periventricular and cortical parenchymal density was observed in bipolar patients.

    • Conclusions:

    • The study identified distinct structural brain abnormalities in bipolar disorder patients, specifically enlarged third ventricles and altered brain density.
    • These findings contribute to understanding the neuropathology of bipolar disorder and its differentiation from other psychotic conditions.