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Microstructured optical fibers sensor modified by deep eutectic solvent: Liquid-phase microextraction and detection

Pavel Pidenko1, Christina Vakh2, Andrey Shishov2

  • 1Institute of Chemistry, Saint Petersburg State University, RU-198504, Saint Petersburg, Russia; Institute of Chemistry, Saratov State University, RU-410012, Saratov, Russia.

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Summary

A novel optical sensor using deep eutectic solvents and hollow-core fibers detects non-steroidal anti-inflammatory drugs in urine. This method offers high sensitivity for drug analysis.

Keywords:
Deep eutectic solventsHollow-core microstructure optical fibersLiquid-phase microextractionNon-steroidal anti-inflammatory drugsOptical fiber sensorUrine

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Area of Science:

  • Analytical Chemistry
  • Materials Science
  • Optoelectronics

Background:

  • Developing sensitive and selective methods for detecting non-steroidal anti-inflammatory drugs (NSAIDs) in biological samples is crucial for therapeutic drug monitoring and clinical diagnostics.
  • Traditional methods for NSAID determination often involve complex sample preparation and expensive instrumentation.
  • Hollow-core microstructure optical fibers (HC-MOFs) offer unique optical properties for sensing applications.

Purpose of the Study:

  • To develop and characterize a novel, sensitive optical sensor for the determination of NSAIDs.
  • To explore the use of deep eutectic solvents (DESs) for modifying HC-MOFs for enhanced sensing capabilities.
  • To implement a liquid-phase microextraction technique integrated with the optical sensor for preconcentration and detection.

Main Methods:

  • Modification of HC-MOFs using DESs derived from natural monoterpenoids and fatty acids for glass surface functionalization.
  • Fabrication of an integrated optical sensor device combining microextraction and spectral measurement.
  • Liquid-phase microextraction of NSAIDs (mefenamic acid, diclofenac, flurbiprofen, ketoprofen) within the DES-modified HC-MOF.
  • Analysis of extracted NSAIDs using transmission spectra measurement.

Main Results:

  • Successful development of a facile procedure for modifying HC-MOFs with DESs.
  • Demonstration of the optical sensor's capability for determining four common NSAIDs in human urine samples.
  • Achieved high sensitivity and selectivity due to the integrated preconcentration step within the analytical device.
  • Obtained low limits of detection (LOD) of 3 μg/L for all target NSAIDs.

Conclusions:

  • The developed optical sensor based on DES-modified HC-MOFs presents a promising, highly sensitive, and selective platform for NSAID determination.
  • The integrated microextraction and optical detection approach simplifies the analytical procedure and enhances detection limits.
  • This innovative sensor technology holds potential for routine clinical analysis and therapeutic drug monitoring of NSAIDs.