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Author Spotlight: Self-Assessment Protocol for Predicting Psoriatic Arthritis in Psoriasis Patients
Published on: March 1, 2024
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Pustular Psoriasis and Associated Musculoskeletal Disorders
Kristina Callis Duffin1, Hervé Bachelez2, Philip J Mease3
1K. Callis Duffin, MD, MS, Department of Dermatology, University of Utah, Salt Lake City, Utah, USA; Kristina.callis@hsc.utah.edu.
The Journal of Rheumatology. Supplement
|June 2, 2021
Summary
Pustular psoriasis (PsO) is a rare skin condition with generalized or localized forms. Recent insights into generalized pustular psoriasis (GPP) genetics are driving new targeted therapies.
Area of Science:
- Dermatology
- Rheumatology
- Genetics
Background:
- Pustular psoriasis (PsO) is an uncommon variant of psoriasis, presenting with generalized or localized pustular eruptions.
- It can involve musculoskeletal or systemic inflammation and may overlap with plaque psoriasis or psoriatic arthritis (PsA).
- Pustulosis is also a feature of SAPHO syndrome and chronic non-bacterial osteomyelitis.
Purpose of the Study:
- To provide an overview of the cutaneous features of pustular psoriasis and SAPHO syndrome.
- To discuss recent genetic insights into generalized pustular psoriasis (GPP).
- To highlight advancements in targeted drug therapies and validated endpoints for pustular psoriasis.
Main Methods:
- Review of cutaneous features of pustular psoriasis and SAPHO syndrome.
- Discussion of recent genetic findings in GPP.
- Overview of emerging therapeutic strategies and endpoint development.
Main Results:
- Pustular psoriasis encompasses various forms, including generalized pustular psoriasis (GPP), palmoplantar pustulosis, and acrodermatitis continua of Hallopeau.
- GPP is characterized by widespread pustular eruption, potential familial links, and association with systemic inflammation.
- Genetic research in GPP is paving the way for novel targeted therapies.
Conclusions:
- Understanding the diverse presentations and genetic underpinnings of pustular psoriasis is crucial for effective management.
- Advances in genetics are enabling the development of targeted therapies for GPP.
- The development of validated endpoints is essential for future clinical trials and treatment assessment.
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