Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Videos

Minimum structural unit required for energy transduction in muscle.

T Yanagida¹, Y Harada

¹Department of Biophysical Engineering, Faculty of Engineering Science, Osaka University, Japan.

Advances in Experimental Medicine and Biology

|January 1, 1988

Summary

This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Gastrointestinal helminths and Taenia spp. in parenteral tissues of free-roaming pigs (Sus scrofa indicus) from hilltribe village at the western border of Thailand.

Tropical biomedicine·2021

Same author

The association between challenging behaviour and symptoms of post-traumatic stress disorder in people with intellectual disabilities: a Bayesian mediation analysis approach.

Journal of intellectual disability research : JIDR·2020

Same author

Differential associations of health literacy with Austrian adolescents' tobacco and alcohol use.

Public health·2019

Same author

Co-occurrence of swine cysticercosis due to <i>Taenia solium</i> and <i>Taenia hydatigena</i> in ethnic minority villages at the Thai-Myanmar border.

Journal of helminthology·2018

Same author

A programmable DNA origami nanospring that reveals force-induced adjacent binding of myosin VI heads.

Nature communications·2016

Same author

A survey of seropositivity to antigen B, an immunodiagnostic antigen for human cystic echinococcosis, in domestic animals in Mongolia.

Parasitology international·2013

Myosin

Area of Science:

Muscle contraction and molecular motors.
Biophysics of cytoskeletal dynamics.

Background:

Actin-myosin interactions are fundamental to muscle contraction.
The precise role of myosin's double-headed structure in filament sliding is debated.

Purpose of the Study:

To investigate the minimum myosin requirement for actin filament sliding.
To determine the sliding distance per ATP hydrolysis cycle.

Main Methods:

Utilized video-fluorescence microscopy to observe actin filament movement.
Experimentally varied the density of myosin heads on single-headed myosin filaments.

Main Results:

Demonstrated that the double-headed structure of myosin is not essential for actin filament sliding.

Related Experiment Videos

Estimated 4 to 16 myosin heads are needed for maximum actin sliding velocity (5 µm/s).

Conclusions:

The study provides insights into the mechanochemical coupling of the actin-myosin motor.
Suggests a sliding distance of at least 40 nm per ATP hydrolysis cycle under unloaded conditions.