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Updated: Nov 3, 2025

Author Spotlight: Functionalizing Metal-Organic Frameworks: Advancements, Challenges, and the Power of Post-Synthetic Ligand Exchange
Published on: June 23, 2023
Broadened bioactivity and enhanced durability of two structurally distinct metal-organic frameworks containing Zn2+
Daiya Kobayashi1, Akira Hamakawa1, Yuki Yamaguchi1
1Nippon Soda Co. Ltd., Chiba Research Center, 12-54 Goi-minamikaigan, Ichihara, Chiba 290-0045, Japan. d.kobayashi@nissogr.com.
Abstract:
Novel metal-organic frameworks (MOFs) based on thiabendazole (TBZ) were developed. The two structurally distinct TBZ-MOFs synthesized in this study exhibited enhanced durability and a broader biocidal spectrum than either individual bioactive species (i.e., Zn2+ and TBZ). The characteristics of each TBZ-MOF are related to the coordination modes among the Zn2+ ions and ligand donors. The difference in water solubility between the two TBZ-MOFs due to the structural design allows for the controlled release of the desired bioactive component.
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