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Association Between Serum Elabela Levels and Chronic Totally Occlusion in Patients with Stable Angina Pectoris

Fethi Yavuz1, Mehmet Kaplan2

  • 1Departamento de Cardiologia, Adıyaman University Training and Research Hospital, Adıyaman - Turquia.

Arquivos Brasileiros De Cardiologia
|June 2, 2021
PubMed

Insights

Serum Elabela levels are lower in patients with chronic total occlusion (CTO) and correlate with poor collateral development. Lower Elabela indicates a higher risk of CTO and weaker collateral circulation.

Area of Science:

  • Cardiovascular Medicine
  • Biomarker Discovery
  • Interventional Cardiology

Background:

  • Elabela's beneficial cardiovascular effects are documented.
  • Chronic total occlusion (CTO) poses significant cardiovascular risks.
  • Collateral circulation is crucial for managing ischemic heart disease.

Purpose of the Study:

  • To compare serum Elabela levels in CTO patients versus controls.
  • To investigate the correlation between Elabela levels and collateral development in CTO patients.

Main Methods:

  • Cross-sectional and prospective study design.
  • Inclusion of 50 CTO patients and 50 control subjects with normal coronary arteries.
  • Measurement of serum Elabela, NT-proBNP, and troponin levels; assessment of collateral development using Rentrop classification.

Main Results:

  • Demographics and routine labs were similar between groups.
  • CTO patients exhibited lower mean Elabela levels but higher NT-proBNP and troponin compared to controls.
  • Elabela levels were independently predictive of CTO and positively correlated with good collateral development (Rentrop class 2-3).

Conclusions:

  • Reduced serum Elabela levels are associated with CTO.
  • Elabela levels correlate with the extent of coronary collateral development.
  • Elabela may serve as a potential biomarker for CTO and collateralization.
Abstract

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