[Effect of isoptin on the central and peripheral hemodynamics in hypokinesia in healthy persons]

Central and peripheral hemodynamics was studied by the radioisotope method employing 131I-labelled albumin, the blood flow in the muscles was investigated (using 133Xe) and the longitudinal rheovasogram of the leg and forearm recorded in 10 healthy male volunteers before, during, and after 45-day antiorthostatic hypokinesia. Five of the examines received isoptin, while the remaining 5 formed the control group. Due to the effect of hypokinesia a tendency towards a a decrease in the circulation volume, a reduced stroke index, an increase in the central venous pressure and peripheral resistance, and a decrease in the muscular blood flow were observed. With the prescription of isoptin the changes in the cardiac index and peripheral resistance were corrected, but there was no esstential effect on the level of the venous pressure and the muscular blood flow.