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Updated: Nov 3, 2025
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Point-Of-Care Ultrasound Screening for Proximal Lower Extremity Deep Venous Thrombosis
Published on: February 10, 2023
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Association between vitamin D levels and lower-extremity deep vein thrombosis: a case-control study
Ufuk Turan Kursat Korkmaz1, Suleyman Ersoy2, Ahmet Yuksel3
1BSc, MD. Assistant Professor, Department of Cardiovascular Surgery, School of Medicine, Bolu Abant Izzet Baysal University, Bolu, Turkey.
Summary
Low vitamin D levels are linked to deep vein thrombosis (DVT). This study found significantly lower serum 25-hydroxyvitamin D (25(OH)D) in DVT patients, suggesting a potential role for vitamin D in DVT prevention.
Area of Science:
- Cardiovascular Medicine
- Endocrinology
- Nutritional Science
Background:
- Vitamin D plays a role in disease pathogenesis and inflammation.
- Vitamin D deficiency can indicate underlying health issues.
- Reduced vitamin D levels are associated with increased cardiovascular disease risk.
Purpose of the Study:
- To investigate the relationship between serum vitamin D levels and deep vein thrombosis (DVT).
- To determine if vitamin D deficiency is a risk factor for DVT.
Main Methods:
- A case-control study was conducted with 280 participants (140 DVT, 140 controls).
- Serum 25-hydroxyvitamin D (25(OH)D) levels were measured and compared between groups.
- Clinical characteristics and comorbidities were recorded.
Main Results:
- Serum 25(OH)D levels were significantly lower in the DVT group compared to controls (P < 0.001).
- Female DVT patients exhibited lower 25(OH)D levels than controls (P = 0.002).
- Logistic regression identified 25(OH)D as a significant predictor of DVT.
Conclusions:
- Deep vein thrombosis patients have lower serum vitamin D levels than controls.
- Vitamin D replacement therapy could be considered for DVT prevention.
- Further large-scale randomized controlled trials are needed to confirm these findings.
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