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Pseudallescheria boydii brain abscess. Complication of an intravenous catheter
R E Pérez1, M Smith, J McClendon
1Infectious Disease Department, University of California, Irvine.
Abstract:
An adult patient survived a brain abscess with Pseudallescheria boydii. She received intraventricular miconazole, 20 mg every 72 hours (minimal inhibitory concentration = 0.4 microgram/ml), and surgery. The abscess resulted from an infected central venous catheter (Port-A-Cath) and steroid therapy. Miconazole caused a ventriculitis. There are 12 reported cases of P. boydii brain abscesses from 1965 to 1985 with only two survivors.
Insights
This case study details the survival of a patient with a Pseudallescheria boydii brain abscess, treated with intraventricular miconazole and surgery. This rare fungal infection has a historically low survival rate.
Area of Science:
- Mycology
- Infectious Diseases
- Neurosurgery
Background:
- Brain abscesses caused by Pseudallescheria boydii are rare and associated with high mortality.
- Fungal brain infections can arise from complications like central venous catheters and immunosuppression (e.g., steroid therapy).