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COVID-19 vaccination in pediatric solid organ transplant recipients-Current state and future directions

Arnaud G L'Huillier1, Monica I Ardura2, Abanti Chaudhuri3

  • 1Faculty of Medicine, Children's Hospital of Geneva, Geneva University Hospitals, Geneva, Switzerland.

Pediatric Transplantation
|June 2, 2021
PubMed

Insights

COVID-19 vaccines are not yet approved for children under 16 or for immunosuppressed individuals like pediatric transplant recipients. More research is needed on vaccine safety and effectiveness in these groups.

Area of Science:

  • Immunology
  • Vaccinology
  • Pediatric Medicine

Background:

  • Population-level COVID-19 immunization is crucial for pandemic control.
  • Several SARS-CoV-2 vaccines show promise in adults but were not tested in children or immunosuppressed populations.
  • Data on COVID-19 vaccine safety, efficacy, and immunogenicity in pediatric solid organ transplant (SOT) recipients are currently lacking.

Purpose of the Study:

  • To review the current status of COVID-19 vaccines specifically for pediatric SOT recipients.
  • To highlight the existing data gaps concerning vaccine safety, immunogenicity, and clinical efficacy in this vulnerable population.

Main Methods:

  • A review of the general status of COVID-19 vaccines was conducted.
  • Focus was placed on pediatric-specific issues and considerations for transplant recipients.

Main Results:

  • The review underscores a significant lack of data regarding COVID-19 vaccination in pediatric SOT recipients.
  • Current understanding of vaccine safety, immunogenicity, and efficacy is limited in both pediatric and transplant populations.

Conclusions:

  • Vaccine trials including children and transplant recipients are ongoing.
  • Further research is essential to determine COVID-19 vaccine safety, immunogenicity, and efficacy in these groups.
  • These studies will guide future research directions for pediatric and transplant populations.
Abstract

Keywords:
COVID-19SARS-CoV-2childrenimmunizationsolid organ transplantationvaccine

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