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Related Concept Videos

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Related Experiment Video

Updated: Nov 3, 2025

External Excitation of Neurons Using Electric and Magnetic Fields in One- and Two-dimensional Cultures
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Thresholds for Transverse Stimulation: Fiber Bundles in a Uniform Field.

N Pourtaheri, W Ying, J Kim

    IEEE Transactions on Neural Systems and Rehabilitation Engineering : a Publication of the IEEE Engineering in Medicine and Biology Society
    |June 2, 2021
    PubMed
    Summary
    This summary is machine-generated.

    Transverse stimulation of cells requires considering external field effects. Approximating cells as holes accurately predicts activation thresholds and firing order in bundles.

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    Area of Science:

    • Biophysics
    • Computational Neuroscience
    • Electrophysiology

    Background:

    • Cable theory models longitudinal fiber stimulation but is insufficient for transverse stimulation.
    • Predicting stimulus thresholds for cells in bundles under transverse fields is challenging.
    • Existing models often overlook the impact of cell presence on external electrical fields.

    Purpose of the Study:

    • To develop a general method for quantifying transverse extracellular stimulation.
    • To compare different computational approaches for predicting cell activation under transverse fields.
    • To accurately determine the applied plate potential (Öpact) required for cell activation.

    Main Methods:

    • Modeling long fibers perpendicular to a uniform field (circular cells in a 2-D domain).
    • Comparing several computational methods against a fully coupled model.
    • Calculating electrical potentials around each cell in a bundle.
    • Utilizing a 'hole model' approximation for cells.

    Main Results:

    • Cell presence significantly affects the external field, crucial for accurate Öpact computation in transverse stimulation.
    • The 'hole model' accurately predicts firing order and Öpact for cells within bundles.
    • Potential profiles from the hole model improve single-cell model accuracy for time-dependent responses.

    Conclusions:

    • Transverse stimulation necessitates considering the influence of cell geometry and arrangement on extracellular fields.
    • The 'hole model' offers an efficient and accurate alternative to complex coupled models for transverse stimulation.
    • This approach extends to various transverse cell stimulation scenarios where cable theory fails and full simulations are computationally prohibitive.