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Related Experiment Video

Updated: Nov 3, 2025

A Precision Medicine Tool for Measurement and Monitoring of Hemoglobin S in Sickle Cell Disease Patients Receiving Transfusion Therapy
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Troponin Elevation in Sickle Cell Disease.

Nuri I Akkus1, Saurabh Rajpal2, Jeffrey Hilbun2

  • 1Division of Cardiology, VAMC, Oklahoma City, Oklahoma, USA.

Medical Principles and Practice : International Journal of the Kuwait University, Health Science Centre
|June 2, 2021
PubMed
Summary

Elevated troponin levels in sickle cell pain crisis patients are not linked to typical heart risks but indicate lower blood counts and higher pulmonary hypertension markers. Further research is needed for these patients.

Keywords:
Pulmonary hypertensionSickle cell diseaseTroponin elevation

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Area of Science:

  • Cardiology
  • Hematology
  • Pulmonology

Background:

  • Sickle cell disease (SCD) is linked to cardiovascular issues, yet troponin's role is unclear.
  • Troponin is not routinely measured in SCD patients, leaving its significance unknown.

Purpose of the Study:

  • To evaluate troponin use in sickle cell pain crisis (SCPC) admissions.
  • To identify factors associated with elevated troponin in SCPC patients.

Main Methods:

  • Retrospective review of 724 patients admitted with SCPC (2006-2011).
  • Comparison of patients with elevated troponin (ET) versus normal troponin (NT).
  • Analysis included demographics, risk factors, pulmonary hypertension markers (tricuspid regurgitant jet velocity ≥3 m/s), and lab tests.

Main Results:

  • Troponin I was measured in 63 patients; 12 (19%) had ET.
  • ET was associated with lower hemoglobin and hematocrit.
  • ET correlated with higher LDH, AST, bilirubin, and pulmonary hypertension (TRV ≥3 m/s).

Conclusions:

  • Troponin elevation in SCPC is uncommon but associated with specific clinical markers.
  • Findings suggest troponin elevation in SCPC is linked to hemolysis and pulmonary hypertension, not traditional cardiovascular risk factors.
  • Troponin measurement is infrequent in SCPC patients, highlighting a gap in cardiac assessment.