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Published on: August 17, 2018
Direct Incorporation of [11C]CO2 into Asymmetric [11C]Carbonates
Abdul Karim Haji Dheere1, Salvatore Bongarzone1, Dinah Shakir1
1Department of Chemistry and Biology, School of Biomedical Engineering and Imaging Sciences, King's College London, King's Health Partners, St. Thomas' Hospital, London, UK.
Abstract:
A novel carbon-11 radiolabelling methodology for the synthesis of the dialkylcarbonate functional group has been developed. The method uses cyclotron-produced short-lived [11C]CO2 (half-life 20.4 min) directly from the cyclotron target in a one-pot synthesis. Alcohol in the presence of base trapped [11C]CO2 efficiently forming an [11C]alkylcarbonate intermediate that subsequently reacted with an alkylchloride producing the di-substituted [11C]carbonate (34% radiochemical yield, determined by radio-HPLC) in 5 minutes from the end of [11C]CO2 cyclotron delivery.
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