Related Experiment Video

Updated: Nov 3, 2025

Cardiac Stress Test Induced by Dobutamine and Monitored by Cardiac Catheterization in Mice
15:45

Cardiac Stress Test Induced by Dobutamine and Monitored by Cardiac Catheterization in Mice

Published on: February 10, 2013

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Bilateral Subarachnoid Hemorrhage and Bilateral Intracranial Hemorrhage With Reversible Cardiomyopathy During

Khuzema Ghafoor1, Hafiz U Ghafoor2, Somwail Rasla2

  • 1Internal Medicine, Atrium Health Navicent, Macon, USA.

Cureus
|June 3, 2021
PubMed

Insights

Dobutamine stress echocardiogram (DSE) can rarely cause serious complications like intracranial hemorrhage (ICH). This case highlights the importance of vigilance for neurological symptoms during DSE, especially with severe hypertension.

Area of Science:

  • Cardiology
  • Neurology
  • Radiology

Background:

  • Dobutamine stress echocardiogram (DSE) is a standard diagnostic tool for coronary artery disease (CAD).
  • While generally safe, DSE carries a very low risk of serious complications, including cerebrovascular accidents (CVA).

Observation:

  • A 39-year-old female without prior cardiac history experienced acute multifocal intracranial hemorrhage (ICH) and subarachnoid hemorrhage (SAH) during a DSE.
  • The patient developed severe symptoms including headache, nausea, and dyspnea after dobutamine infusion and atropine administration.

Findings:

  • Computed tomography head confirmed acute multifocal bilateral SAH and left frontal/right parieto-occipital ICH.
  • Dobutamine infusion can exacerbate hypertension, a known risk factor for ICH.

Implications:

  • This case underscores the critical need for heightened awareness of neurological symptoms during DSE.
  • Clinicians should maintain a low threshold for further evaluation in patients developing severe hypertension or neurological signs during DSE.
  • Increased vigilance is warranted to mitigate the rare but severe risk of ICH associated with DSE.

Keywords:
cerebrovascular accidentdobutamine stress echocardiographyheadachehypertensionintracranial hemorrhagesubarachnoid hemorrhagetakosubo cardiomyopathy

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