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Related Concept Videos

Targeted Cancer Therapies02:57

Targeted Cancer Therapies

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The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
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Abnormal Proliferation02:23

Abnormal Proliferation

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Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the...
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The Retinoblastoma Gene01:20

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Tumor suppressor genes are normal genes that can slow down cell division, repair DNA mistakes, or program the cells for apoptosis in case of irreparable damage. Hence, they play an essential role in preventing the proliferation of damaged cells.
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The Ras Gene02:38

The Ras Gene

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The Ras-gene-encoded proteins are regulators of signaling pathways controlling cell proliferation, differentiation, or cell survival. The Ras-gene family in humans constitutes three primary members—the HRas, NRas, and KRas. These genes code for four functionally distinct yet closely related proteins—the HRas, NRas, KRas4A, and KRas4B. The involvement of mutant Ras genes in human cancer was first discovered in 1982 and is among the most common causes of human tumorigenesis.
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Small GTPases - Ras and Rho01:24

Small GTPases - Ras and Rho

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Ras and Rho are small monomeric GTPases that act downstream of receptor tyrosine kinase (RTK) and regulate various cellular processes. These GTPases switch between active and inactive states by binding to guanine nucleotides.
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mTOR Signaling and Cancer Progression03:03

mTOR Signaling and Cancer Progression

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The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
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Related Experiment Video

Updated: Nov 3, 2025

Defining Gene Functions in Tumorigenesis by Ex vivo Ablation of Floxed Alleles in Malignant Peripheral Nerve Sheath Tumor Cells
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Defining Gene Functions in Tumorigenesis by Ex vivo Ablation of Floxed Alleles in Malignant Peripheral Nerve Sheath Tumor Cells

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Rac1, A Potential Target for Tumor Therapy.

Jiaxin Liang1, Linda Oyang1, Shan Rao1

  • 1Hunan Key Laboratory of Cancer Metabolism, Hunan Cancer Hospital and the Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, China.

Frontiers in Oncology
|June 3, 2021
PubMed
Summary

RAS-related C3 botulinum toxin substrate 1 (Rac1) is a key protein in Rho GTPases, crucial for cell functions and tumor progression. Targeting Rac1 shows promise for novel cancer therapies and overcoming immune escape.

Keywords:
Rac1cancer stemnessmetastasistherapy resistancetumorigenesis

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Testing Targeted Therapies in Cancer using Structural DNA Alteration Analysis and Patient-Derived Xenografts
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Testing Targeted Therapies in Cancer using Structural DNA Alteration Analysis and Patient-Derived Xenografts

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RhoC GTPase Activation Assay
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Related Experiment Videos

Last Updated: Nov 3, 2025

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Testing Targeted Therapies in Cancer using Structural DNA Alteration Analysis and Patient-Derived Xenografts
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RhoC GTPase Activation Assay
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Area of Science:

  • Molecular Biology
  • Oncology
  • Cell Biology

Background:

  • RAS-related C3 botulinum toxin substrate 1 (Rac1) is a Rho GTPase involved in cytoskeleton regulation.
  • Rac1 influences cell adhesion, morphology, and movement.
  • Elevated Rac1 expression correlates with poor prognosis in various cancers.

Purpose of the Study:

  • To review the multifaceted roles of Rac1 in cancer development and progression.
  • To explore Rac1's involvement in tumor cell biology, stemness, and the tumor microenvironment.
  • To highlight Rac1 as a potential therapeutic target for cancer treatment.

Main Methods:

  • Literature review of studies on Rac1 function in cancer.
  • Analysis of Rac1's involvement in cell cycle, apoptosis, proliferation, invasion, migration, and angiogenesis.
  • Examination of Rac1's role in tumor stem cells and immune escape.

Main Results:

  • Rac1 is implicated in promoting tumor occurrence and progression through various cellular mechanisms.
  • Rac1 plays a significant role in anti-tumor therapy resistance and immune evasion.
  • Rac1 inhibitors demonstrate potential in cancer prevention and treatment.

Conclusions:

  • Rac1 is a critical regulator in cancer, influencing multiple hallmarks of the disease.
  • Rac1 represents a promising therapeutic target for developing novel anti-cancer strategies.
  • Further research into Rac1's functions and inhibition is warranted.