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Related Experiment Video

Updated: Nov 3, 2025

An Orthotopic Model of Murine Bladder Cancer
09:07

An Orthotopic Model of Murine Bladder Cancer

Published on: February 6, 2011

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Perspective: Humanized Pig Models of Bladder Cancer.

Natália Vieira Segatto1, Camila Bonemann Bender1, Fabiana Kommling Seixas1

  • 1Postgraduate Program in Biotechnology, Cancer Biotechnology Laboratory, Technology Development Center, Federal University of Pelotas, Pelotas, Brazil.

Frontiers in Molecular Biosciences
|June 3, 2021
PubMed
Summary

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Bladder cancer (BC) research needs better models. Pigs offer a promising large animal model for developing humanized bladder cancer models, improving therapy and diagnostic screening.

Area of Science:

  • Oncology
  • Translational Medicine
  • Animal Models

Background:

  • Bladder cancer (BC) is a prevalent malignancy with high recurrence and treatment costs.
  • Current animal models (murine, canine) have limitations in size, clinical translatability, and spontaneous occurrence.
  • Need for improved biological models to evaluate novel bladder cancer therapies.

Purpose of the Study:

  • To review the genetic basis of bladder cancer.
  • To assess existing bladder cancer animal models and their limitations.
  • To propose pigs as a suitable large animal model for humanized bladder cancer research.

Main Methods:

  • Review of genetic alterations in human bladder cancer.
  • Analysis of limitations in current murine and canine bladder cancer models.
Keywords:
bladder cancerlarge animal modeloncopigpigurothelial carcinoma

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  • Proposal for developing genetically defined porcine models mimicking human BC mutations (e.g., FGFR3, PIK3CA, TP53).

    • Main Results:

    • Pigs possess anatomical, physiological, and genetic similarities to humans, suitable for biomedical research.
    • Pigs can be utilized to experimentally induce tumors, facilitating the creation of personalized models.
    • Genetically defined porcine models can incorporate key human BC driver mutations.

    Conclusions:

    • Pigs represent a valuable large animal model for developing humanized bladder cancer.
    • These models will aid in studying bladder cancer pathology and screening new treatments.
    • Development of robust porcine models is crucial for advancing bladder cancer diagnostics and therapeutics.