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Bone marrow transplant is a potential cure for several diseases, including cancer and specific genetic disorders. Notably, this procedure is applicable for patients suffering from aplastic anemia, certain types of leukemia, severe combined immunodeficiency disease (SCID), Hodgkin's disease, non-Hodgkin's lymphoma, multiple myeloma, thalassemia, sickle-cell disease, and certain cancers.
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Tissue transplantation is a significant medical procedure involving the transfer of cells, tissues, or organs from a donor to a recipient, with the primary aim of restoring lost functions. This procedure is crucial in treating a broad spectrum of diseases, including kidney diseases, liver failure, heart disease, and certain types of cancers.
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All blood and immune cells are produced from the multipotent hematopoietic stem cells (HSCs) by the process of hematopoiesis. However, they all have a limited life span. In addition, many are depleted in immune surveillance or combatting an injury or infection. This makes blood one of the most regenerative tissues. Hematopoiesis helps replenish these blood and immune cells, restoring the body's normal functioning. However, overproduction of blood and immune cells can make them cancerous or...
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[Allogeneic hematopoietic stem cell transplantation : general principles and recent progress].

J Narinx1, S Servais1, F Baron1

  • 1Service d'Hématologie, CHU de Liège et CHR de la Citadelle, Liège, Belgique.

Revue Medicale De Liege
|June 3, 2021
PubMed
Summary

Hematopoietic stem cell transplantation offers a cure for various blood disorders. Ongoing advancements in donor selection, conditioning, and immunosuppression are improving patient outcomes and reducing transplant-related complications.

Keywords:
Conditioning regimenDonor choiceGraftHematopoietic stem cell transplantationHost DiseaseVersus

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Area of Science:

  • Hematology
  • Oncology
  • Immunology

Background:

  • Hematopoietic stem cell transplantation (HSCT) is a vital treatment for hematological diseases.
  • Significant progress has been made in reducing HSCT-related morbidity and mortality.

Purpose of the Study:

  • To outline the fundamental principles of HSCT.
  • To review advancements in post-transplant patient management worldwide.

Main Methods:

  • Review of current literature on HSCT.
  • Analysis of evolving strategies in donor selection, conditioning regimens, and immunosuppression.
  • Discussion of patient management protocols post-transplantation.

Main Results:

  • Evolving donor selection, conditioning, and immunosuppression strategies are key to improved HSCT outcomes.
  • Enhanced post-transplant care protocols contribute to reduced complications.

Conclusions:

  • HSCT remains a powerful therapeutic option for hematological conditions.
  • Continuous innovation in HSCT procedures and patient care is crucial for optimizing long-term survival and quality of life.