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Treatment Resistant Cancers02:56

Treatment Resistant Cancers

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Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
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[Locally-advanced cervix cancer : multidisciplinary management].

L Lapaille1, M De Cuypere2, F Goffin2

  • 1Service d'Oncologie médicale, CHU Liège, Belgique.

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|June 3, 2021
PubMed
Summary

Human papillomavirus (HPV) is linked to most cervical cancers. Advanced stages have improved survival due to better imaging and standard treatments like radiation and chemotherapy, with new therapies under study.

Keywords:
BrachytherapyChemotherapyLocally advancedRadiotherapyCervical cancer

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Area of Science:

  • Oncology
  • Gynecologic Oncology
  • Radiation Oncology

Background:

  • Cervical cancer is a major global health concern for women, often diagnosed at advanced stages.
  • Human papillomavirus (HPV) infection is implicated in over 95% of cervical cancer cases.
  • Despite advances, locally advanced cervical cancer presents significant survival and treatment challenges.

Purpose of the Study:

  • To review the evolving management strategies for locally advanced cervical cancer.
  • To highlight the impact of imaging technologies on treatment outcomes.
  • To discuss current standard treatments and emerging therapeutic approaches.

Main Methods:

  • Review of current treatment protocols for locally advanced cervical cancer.
  • Analysis of the role of imaging in treatment planning and delivery.
  • Evaluation of standard chemoradiation and brachytherapy techniques.
  • Assessment of ongoing research into neoadjuvant, adjuvant, and novel therapies like immunotherapy.

Main Results:

  • Significant improvements in survival and local control for locally advanced cervical cancer have been achieved.
  • Implementation of advanced imaging has led to reduced treatment toxicity.
  • Standard treatment involves concurrent chemoradiation followed by brachytherapy.
  • The efficacy of neoadjuvant/adjuvant chemotherapy and immunotherapy is under active investigation.

Conclusions:

  • Modern management strategies, integrating imaging and standard therapies, have improved outcomes for locally advanced cervical cancer.
  • Ongoing research into novel agents like immunotherapy holds promise for further enhancing treatment efficacy.
  • Continued evaluation of chemotherapy and innovative treatments is crucial for advancing cervical cancer care.