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Resting-State Network Alterations Differ between Alzheimer's Disease Atrophy Subtypes.

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Cerebral Cortex (New York, N.Y. : 1991)
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PubMed
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Alzheimer's disease (AD) brain network differences were found across four atrophy subtypes. These subtypes show distinct functional connectivity, clinical, and biomarker variations, improving our understanding of AD heterogeneity.

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Area of Science:

  • Neuroscience
  • Brain Imaging
  • Systems Biology

Background:

  • Alzheimer's disease (AD) exhibits heterogeneous atrophy patterns.
  • Understanding the brain network properties of these subtypes is crucial.

Purpose of the Study:

  • To investigate differences in functional connectivity and network properties among AD atrophy subtypes.
  • To correlate these network differences with clinical and biomarker data.

Main Methods:

  • Analysis of resting-state functional magnetic resonance imaging (rs-fMRI) data from two independent cohorts (DZNE and ADNI).
  • Data-driven clustering to identify AD atrophy subtypes.
  • Assessment of intra-network connectivity (INC), global, and nodal network properties.

Main Results:

  • Four AD atrophy subtypes identified: medio-temporal (S-MT), limbic (S-L), diffuse (S-D), and mild (S-MA).
  • S-MT and S-D subtypes showed reduced INC in several networks and decreased global efficiency and clustering coefficient in specific brain regions.
  • S-L exhibited nodal network failure despite limbic atrophy, while S-MA showed significant global network failure with mild clinical impairment.

Conclusions:

  • Distinct functional connectivity profiles characterize different Alzheimer's disease atrophy subtypes.
  • These network differences are associated with specific clinical and cerebrospinal fluid (CSF) biomarker alterations.
  • Identifying these subtypes enhances the understanding of AD heterogeneity and may inform personalized treatment strategies.