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Relationship between free fatty acids, body mass index and depressive symptoms in patients with chronic heart failure

Hua Yang1, Yan Li2, Xing Su3

  • 1Department of Cardiology, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, China.

Nursing Open
|June 3, 2021
PubMed

Insights

Depressive symptoms are common in chronic heart failure (CHF) patients. High free fatty acids (FFAs) and low body mass index (BMI) are identified as significant risk factors for depression in this population.

Area of Science:

  • Cardiology
  • Psychiatry
  • Metabolic Disorders

Background:

  • Chronic heart failure (CHF) is a complex condition associated with significant psychological distress.
  • Depressive symptoms are frequently observed in CHF patients, impacting quality of life and clinical outcomes.
  • The interplay between metabolic factors and mental health in CHF requires further investigation.

Purpose of the Study:

  • To determine the prevalence of depressive symptoms in patients diagnosed with chronic heart failure.
  • To analyze the association between serum free fatty acids (FFAs) and depressive symptoms in CHF patients.
  • To investigate the relationship between body mass index (BMI) and depressive symptoms among individuals with CHF.

Main Methods:

  • A cross-sectional study was conducted involving 195 hospitalized patients with CHF.
  • Data were collected using questionnaires, including the Zung Self-rating Depression Scale (SDS).
  • Pearson's correlation and multiple linear regression analyses were employed to assess relationships between FFAs, BMI, and depressive symptoms.

Main Results:

  • A high prevalence of depressive symptoms was found, with 71.28% of CHF patients affected.
  • Elevated serum FFAs and lower BMI were significantly associated with increased depressive symptoms (p < 0.01).
  • High FFAs and low BMI were identified as independent risk factors for depressive symptoms in CHF patients.

Conclusions:

  • Depressive symptoms represent a significant comorbidity in chronic heart failure patients.
  • Interventions targeting nutritional support and metabolic health, particularly addressing FFAs and BMI, may help alleviate depressive symptoms in CHF.
  • Further research into the pathophysiological mechanisms linking metabolic dysregulation and depression in CHF is warranted.
Abstract

Keywords:
body mass indexchronic heart failuredepressive symptomsfree fatty acidspsychological nursing

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