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Published on: February 20, 2021

Microdosimetry modeling with auger emitters in generalized cell geometry.

Teresa L Palmer¹, Kinga Tkacz-Stachowska¹, Roar Skartlien¹

¹Institute for Energy Technology (IFE), PO Box 40, NO-2027 Kjeller, Norway.

Physics in Medicine and Biology

|June 3, 2021

Summary

A new microdosimetry model predicts cell viability after irradiation by auger electrons. This model found that terbium-161 (Tb-161) is more effective than lutetium-177 (Lu-177) for prostate cancer treatment.

Keywords:

microdosimetry computer modeling; local radioimmunotherapy; targeted radiation therapy; auger emitters

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Area of Science:

Medical physics
Radiological sciences
Computational biology

Background:

Auger electron-emitting radionuclides are used in targeted radionuclide therapy.
Accurate prediction of cell viability requires detailed microdosimetry, especially for irregular cell shapes.
Understanding the impact of electron range on cellular dose is crucial for treatment efficacy.

Purpose of the Study:

To develop and validate a microdosimetry model for predicting cell viability in non-spherical cells irradiated by low-energy auger electrons.
To compare the therapeutic potential of lutetium-177 (Lu-177) and terbium-161 (Tb-161) for prostate cancer treatment using this model.
To evaluate the role of short-range auger electrons in determining the relative efficacy of different radionuclides.

Main Methods:

Developed a microdosimetry model using image-derived cell geometries and distance probability distribution functions (PDFs).
Calculated radiation dose distributions using Monte Carlo simulations for electron energies below 50 eV.
Compared computational predictions with experimental cell survival data for LNCaP prostate cancer cells treated with Lu-177 and Tb-161 conjugated to PSMA.

Main Results:

The microdosimetry model accurately predicted cell viability for irregular cell geometries.
Terbium-161 (Tb-161) demonstrated higher therapeutic efficiency than lutetium-177 (Lu-177).
The enhanced efficacy of Tb-161 was attributed to its short-range auger electrons.

Conclusions:

Imaging-based microdosimetry is a viable approach for predicting cell viability and therapeutic effects.
Short-range auger electrons play a significant role in the efficacy of targeted radionuclide therapy.
The developed model can aid in selecting optimal radionuclides for cancer treatment.