Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Disorders of Leukocytes01:27

Disorders of Leukocytes

1.4K
Leukocyte disorders can lead to either leukopenia, characterized by an abnormally low leukocyte count, or leukocytosis, marked by a very high leukocyte number.
Leukopenia may result from bone marrow disorders, autoimmune diseases, and infectious diseases. For example, conditions such as multiple myeloma and aplastic anemia can impair the bone marrow's ability to produce adequate leukocytes. Similarly, autoimmune diseases like lupus and viral infections such as HIV can prompt the immune...
1.4K
Rous Sarcoma Virus (RSV) and Cancer01:03

Rous Sarcoma Virus (RSV) and Cancer

5.7K
Rous Sarcoma virus or RSV was discovered by F. Peyton Rous in the year 1911 as a filterable transmissible agent that could cause tumors in chickens. He won a Nobel Prize for this discovery in 1966. His experiments clearly demonstrated that some cancers could be caused by infectious agents and led to the discovery of many more cancer-causing viruses in animals as well as humans.
RSV is a retrovirus that contains two copies of a plus-strand  RNA genome. Its genome consists of four main open...
5.7K
Mechanisms of Retrovirus-induced Cancers01:51

Mechanisms of Retrovirus-induced Cancers

5.6K
Retroviruses are RNA viruses that have been shown to cause cancers in diverse species, including chickens, mice, cats, and monkeys. The RNA genomes of these viruses are first reverse-transcribed into single and then double-stranded DNA (dsDNA) copies. This dsDNA called proviral DNA then integrates into the host genome. Subsequently, the host cell transcribes the proviral DNA in concert with the chromosomal DNA. This leads to the production of viral RNA and proteins that assemble at the host...
5.6K
Primary Lymphoid Organs01:16

Primary Lymphoid Organs

12.8K
Primary lymphoid organs are pivotal in the formation, development, and maturation of lymphocytes, the white blood cells that serve as the backbone of our immune system. This crucial function underscores their fundamental role in maintaining our overall health and immunity. The two primary lymphoid organs of prime importance are the red bone marrow and the thymus.
The red bone marrow is a soft, spongy tissue nestled in the interior of long bones such as the humerus and femur. It is the site...
12.8K
Acute Pyelonephritis II: Diagnostic Studies and Management01:28

Acute Pyelonephritis II: Diagnostic Studies and Management

98
Introduction:For diagnosing acute pyelonephritis, a comprehensive patient history is collected to identify symptoms such as dysuria, frequent or urgent urination, flank pain, or costovertebral angle (CVA) tenderness that may suggest a kidney infection.Physical ExaminationDuring the physical examination, CVA tenderness is assessed. This involves gentle percussion over the costovertebral angle, where tenderness often indicates a kidney infection.Diagnostic TestsUrinalysis: Used to identify white...
98
Bone Marrow Sampling and Transplants01:22

Bone Marrow Sampling and Transplants

603
Bone marrow transplant is a potential cure for several diseases, including cancer and specific genetic disorders. Notably, this procedure is applicable for patients suffering from aplastic anemia, certain types of leukemia, severe combined immunodeficiency disease (SCID), Hodgkin's disease, non-Hodgkin's lymphoma, multiple myeloma, thalassemia, sickle-cell disease, and certain cancers.
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy...
603

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Associations Between Routine Vaccinations and the Risk of New-Onset Idiopathic Uveitis.

American journal of ophthalmology·2026
Same author

Impact of decentralised, community-led molecular STI point-of-care testing on testing practices in remote First Nations communities in Australia.

Sexually transmitted infections·2026
Same author

Integrated proteogenomic and metabolomic profiling of acute myeloid leukemias to identify molecular subtypes and associated therapy targets.

Nature cancer·2026
Same author

Safety and efficacy of transcatheter aortic valve implantation in bicuspid aortic valve stenosis: a propensity-matched multicentre study.

Acta cardiologica·2026
Same author

One-year CALM Outcomes: Data From a Real-world Registry Study of the 0.18-mg Fluocinolone Acetonide Intravitreal Implant for the Treatment of Patients With Non-infectious Uveitis Affecting the Posterior Segment.

Ophthalmic surgery, lasers & imaging retina·2026
Same author

Quality Improvement in Vitreoretinal Surgery: Single-Center Report on Utility of Routine Intravenous Fluids in Pars Plana Vitrectomy.

Journal of vitreoretinal diseases·2026
Same journal

Acute Paracentral Scotoma Following Cosmetic Penile Filler Injection.

Retinal cases & brief reports·2026
Same journal

Intravitreous Methotrexate and Rituximab for Bilateral Diffuse Uveal Melanocytic Proliferation (BDUMP).

Retinal cases & brief reports·2026
Same journal

Multimodal imaging of ASHH in a case of Scrub Typhus Retinopathy.

Retinal cases & brief reports·2026
Same journal

Pathogenic Variants in HGSNAT associated with Autosomal Recessive Retinitis Pigmentosa without Overt Sanfilippo Syndrome.

Retinal cases & brief reports·2026
Same journal

Macular Choroidal Neovascularization in Peripapillary Hyperreflective Ovoid Mass-Like Structures (PHOMS): case report.

Retinal cases & brief reports·2026
Same journal

Endogenous Streptococcus Anginosus Endophthalmitis: A Case Report and Review of the Literature.

Retinal cases & brief reports·2026
See all related articles

Related Experiment Video

Updated: Nov 3, 2025

Murine Model of Leukemia Relapse to Induction Chemotherapy for Acute Lymphoblastic Leukemia
08:31

Murine Model of Leukemia Relapse to Induction Chemotherapy for Acute Lymphoblastic Leukemia

Published on: October 17, 2025

123

PSEUDOPANUVEITIS AS A HARBINGER FOR SYSTEMIC LEUKEMIA RECURRENCE.

Marcus T Altman1, Zane Staubach2, Jennifer Dunlap2

  • 1Casey Eye Institute, Oregon Health & Science University, Portland, OR.

Retinal Cases & Brief Reports
|June 3, 2021
PubMed
Summary
This summary is machine-generated.

Ocular leukemia recurrence, presenting as pseudohypopyon, uveal mass, and retinal detachment, can precede systemic relapse in patients with pre-B acute lymphoblastic leukemia (ALL). This presentation signals impending leukemia recurrence.

More Related Videos

Comprehensive Protocol to Sample and Process Bone Marrow for Measuring Measurable Residual Disease and Leukemic Stem Cells in Acute Myeloid Leukemia
09:57

Comprehensive Protocol to Sample and Process Bone Marrow for Measuring Measurable Residual Disease and Leukemic Stem Cells in Acute Myeloid Leukemia

Published on: March 5, 2018

29.9K
In Ovo Xenografting of Patient-Derived Acute Lymphoblastic Leukemia (ALL) Cells (PDX-ALL)
06:48

In Ovo Xenografting of Patient-Derived Acute Lymphoblastic Leukemia (ALL) Cells (PDX-ALL)

Published on: August 1, 2025

281

Related Experiment Videos

Last Updated: Nov 3, 2025

Murine Model of Leukemia Relapse to Induction Chemotherapy for Acute Lymphoblastic Leukemia
08:31

Murine Model of Leukemia Relapse to Induction Chemotherapy for Acute Lymphoblastic Leukemia

Published on: October 17, 2025

123
Comprehensive Protocol to Sample and Process Bone Marrow for Measuring Measurable Residual Disease and Leukemic Stem Cells in Acute Myeloid Leukemia
09:57

Comprehensive Protocol to Sample and Process Bone Marrow for Measuring Measurable Residual Disease and Leukemic Stem Cells in Acute Myeloid Leukemia

Published on: March 5, 2018

29.9K
In Ovo Xenografting of Patient-Derived Acute Lymphoblastic Leukemia (ALL) Cells (PDX-ALL)
06:48

In Ovo Xenografting of Patient-Derived Acute Lymphoblastic Leukemia (ALL) Cells (PDX-ALL)

Published on: August 1, 2025

281

Area of Science:

  • Ophthalmology
  • Hematology
  • Oncology

Background:

  • Pre-B-cell acute lymphoblastic leukemia (ALL) is a significant hematologic malignancy.
  • Remission following treatment, such as hematopoietic stem cell transplant, can be followed by relapse.
  • Intraocular involvement in leukemia is a known but complex complication.

Observation:

  • A patient with pre-B-cell ALL in remission developed recurrent intraocular leukemia.
  • Ocular findings included pseudohypopyon, uveal mass, and serous retinal detachment.
  • These ocular signs consistently preceded systemic leukemia recurrence.

Findings:

  • The patient experienced alternating ocular leukemia in both eyes during periods of remission.
  • Bone marrow biopsies confirmed impending or overt systemic leukemia relapse.
  • Orbital radiation successfully resolved the ocular manifestations.

Implications:

  • The described ocular findings (pseudohypopyon, uveal mass, serous retinal detachment) may serve as an early warning sign for systemic pre-B ALL recurrence.
  • Recognition of this pattern, termed pseudopanuveitis, is crucial for timely intervention.
  • This highlights the importance of comprehensive ophthalmologic evaluation in leukemia patients.