⁶⁸Ga-PSMA PET/CT Versus ¹⁸F-FDG PET/CT for Imaging of Hepatocellular Carcinoma

This study aimed to compare the metabolic parameters obtained from ¹⁸fluorine-fluorodeoxyglucose (¹⁸F-FDG) positron emission tomography/computed tomography (PET/CT) and gallium-68 (⁶⁸Ga)-prostate-specific membrane antigen (PSMA) PET/CT and investigate the relationship between serum alpha-fetoprotein and PET scan parameters in patients with hepatocellular carcinoma.

Fourteen patients were recruited after dynamic magnetic resonance imaging (MRI) of the upper abdomen, and ¹⁸F-FDG and ⁶⁸Ga-PSMA PET/CT imaging studies were conducted. Regions of interest (ROIs) were drawn from lesion-free liver tissue, abdominal aorta (A), and right medial gluteal muscle (G) for the background activity. Maximum standard uptake value (SUV_max) of these regions were compared with the SUV_max of primary tumor (T).

On visual assessment, five patients (36%) experienced low ¹⁸F-FDG uptake in the primary lesion, three patients (21%) experienced moderate uptake, and six patients (43%) experienced high uptake. However, only one patient (7%) showed low ⁶⁸Ga-PSMA uptake, two patients (14%) showed moderate uptake, and 11 patients (79%) showed high uptake. Four patients with a low ¹⁸F-FDG uptake showed high ⁶⁸Ga-PSMA uptake, while one patient exhibited low uptake with both ¹⁸F-FDG and ⁶⁸Ga-PSMA. The number of lesions on ⁶⁸Ga-PSMA PET/CT and MRI was significantly higher than ¹⁸F-FDG PET/CT (p=0.042 and 0.026, respectively). T/A and T/G values were significantly higher in ⁶⁸Ga-PSMA than ¹⁸F-FDG (p=0.002 and 0.002, respectively).

⁶⁸Ga-PSMA PET/CT is superior to ¹⁸F-FDG PET/CT in the staging of hepatocellular carcinoma. High ⁶⁸Ga-PSMA uptake could be promising for PSMA-targeted radionuclide treatments.