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Neoadjuvant Immunotherapy in Melanoma - The New Frontier

Alexander M Menzies1,2,3, Richard A Scolyer1,2,4, Georgina V Long5,2,3

  • 1Melanoma Institute Australia, The University of Sydney, Sydney, Australia.

Clinical Cancer Research : an Official Journal of the American Association for Cancer Research
|June 4, 2021
PubMed

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Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
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Cancer treatment vaccines are a rapidly evolving field that offers a promising approach to immunotherapy. Unlike traditional vaccines that prevent diseases, cancer treatment vaccines are designed to treat existing cancers by stimulating the immune system to recognize and attack cancer cells.
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
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