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Related Concept Videos

Treatment Resistant Cancers02:56

Treatment Resistant Cancers

Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
Treatment Resistent Cancers02:56

Treatment Resistent Cancers

Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...

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Voluntary Breath-hold Technique for Reducing Heart Dose in Left Breast Radiotherapy
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Inter-institutional Variation in Intensity-modulated Radiotherapy for Breast Cancer in Korea (KROG 19-01).

Kyubo Kim1, Minsoo Chun2, Hyeongmin Jin2

  • 1Department of Radiation Oncology, Ewha Womans University College of Medicine, Seoul, Republic of Korea.

Anticancer Research
|June 4, 2021
PubMed
Summary

Intensity-modulated radiation therapy (IMRT) for breast cancer shows significant variations in target delineation and planning across institutions. Standardized protocols are crucial for consistent treatment outcomes in breast IMRT.

Keywords:
Breast cancerdose-volume constraintintensity-modulated radiation therapytarget volumevariation

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Area of Science:

  • Oncology
  • Radiation Oncology
  • Medical Physics

Background:

  • Intensity-modulated radiation therapy (IMRT) is increasingly used for breast cancer treatment.
  • Variations in treatment planning can impact patient outcomes.

Purpose of the Study:

  • To assess inter-institutional variability in target delineation and IMRT planning for breast cancer.
  • To evaluate the impact of these variations on dose distribution to organs at risk.

Main Methods:

  • Two left breast cancer cases (breast-conserving surgery and mastectomy) were used for evaluation.
  • Target volumes and organs at risk were delineated by 21 participating institutions.
  • IMRT plans, including nodal irradiation, were analyzed.

Main Results:

  • Significant variations in planning target volume (PTV) were observed, up to 3x for BCS and 5x for mastectomy cases.
  • Mean heart doses varied widely (3.3–24.1 Gy for BCS, 5.0–26.5 Gy for mastectomy).
  • Ipsilateral lung V20 ranged from 4.7% to 57.4% (BCS) and 16.4% to 55.5% (mastectomy).

Conclusions:

  • Substantial heterogeneity exists in breast cancer IMRT target delineation and planning.
  • The observed variations necessitate the development of standardized protocols for breast IMRT.