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Related Concept Videos

Clinical Applications of Epidermal Stem Cells01:19

Clinical Applications of Epidermal Stem Cells

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Epidermal stem cells (EpiSCs) are mainly located at the basal layer of the epidermis. These cells repair minor injuries of the skin and replace dead skin cells. However, EpiSCs’ cannot heal severe wounds such as major burns or those from diabetes or hereditary disorders. In such cases, culturing the epidermal stem cells from the patient is possible and has yielded successful treatment options, such as laboratory-grown skin grafts. These grafts are synthesized using a patient’s own...
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After cellular or tissue damage, the resident stem cells present in the human body can locally repair and regenerate the damaged tissue or organ. However, even though some tissues do not have stem cells, they can repair and regenerate with the help of pre-existing cells. For example, beta cells of the pancreas and hepatocytes of the liver can divide to renew and regenerate the tissue. Here, both cell division and cell death are well regulated by homeostasis.
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The skin is divided into epidermis, dermis, and hypodermis, the skin's outermost, middle, and inner layers. The human epidermal layer regularly undergoes renewal, where old, dead cells are replaced by new cells. Epidermal stem cells or EpiSCs divide and differentiate to restore the lost cells. For the renewal process, some EpiSCs continuously self-renew. In contrast, few others differentiate into transit-amplifying cells, which later form prickle or spinous cells, followed by granular...
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Related Experiment Video

Updated: Nov 3, 2025

Combination of Microstereolithography and Electrospinning to Produce Membranes Equipped with Niches for Corneal Regeneration
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Innovative Indigenous Cost-effective Bilaminar Dermal Regeneration Template.

Koliyath Shijina1, Ravi K Chittoria2, Vinayak Chavan1

  • 1Department of Plastic Surgery, Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER), Pondicherry, India.

Journal of Cutaneous and Aesthetic Surgery
|June 4, 2021
PubMed
Summary

This study explored an affordable, indigenous bilaminar dermal regeneration template for burn wound management. The innovative approach offers a cost-effective solution for developing countries, improving accessibility to advanced burn care.

Keywords:
Bilaminar dermal regeneration templateindigenousinnovative

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Area of Science:

  • Regenerative medicine
  • Biomaterials science
  • Plastic and reconstructive surgery

Background:

  • Advanced burn wound management utilizes various treatment options and dressings.
  • Bilaminar dermal regeneration templates are often unaffordable and unavailable in developing countries due to high costs.

Purpose of the Study:

  • To evaluate an innovative, indigenous, and cost-effective bilaminar dermal regeneration template for burn wound management.
  • To assess the feasibility of using affordable biomaterials for dermal regeneration in resource-limited settings.

Main Methods:

  • An experimental study was conducted in a tertiary care plastic surgery department.
  • The study involved the application of a novel indigenous bilaminar dermal regeneration template on burn wounds.

Main Results:

  • Preliminary findings suggest the potential of the indigenous template as a viable and cost-effective alternative.
  • Further research is needed to establish efficacy and long-term outcomes.

Conclusions:

  • An indigenous bilaminar dermal regeneration template presents a promising, affordable solution for burn wound care in developing nations.
  • This innovation could significantly improve patient outcomes by increasing access to advanced regenerative treatments.