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Updated: Nov 3, 2025

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Controlling cellular organization in bioprinting through designed 3D microcompartmentalization.

Mohamadmahdi Samandari, Fatemeh Alipanah1, Keivan Majidzadeh-A2

  • 1Applied Physiology Research Center, Department of Physiology, Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan 81746-73461, Iran.

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|June 4, 2021
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Summary

Researchers developed a novel method for 3D printing multicompartmental hydrogel fibers. This technique uses internal microfilaments to precisely control cellular orientation, advancing tissue engineering and biofabrication.

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Area of Science:

  • Biomaterials Science
  • Tissue Engineering
  • Microfluidics

Background:

  • Controlling cellular organization is vital for creating functional tissue-engineered scaffolds.
  • Current methods struggle to incorporate cell-size physiochemical cues into 3D scaffolds for directing cellular organization.

Purpose of the Study:

  • To develop a rapid, cost-effective method for printing multicompartmental hydrogel fibers with internal microtopographies.
  • To demonstrate control over cellular orientation within these engineered fibers.

Main Methods:

  • Utilized a static mixer integrated into a coaxial microfluidic device for continuous printing.
  • Fabricated alginate/gelatin-methacryloyl (GelMA) hydrogel fibers with patterned internal microfilaments.
  • Manipulated flow parameters during printing to tailor microtopography and cellular alignment.

Main Results:

  • Achieved precise control over internal microtopography organization and subsequent cellular alignment within hydrogel fibers.
  • Demonstrated excellent cell spreading and alignment despite the large fiber diameter.
  • Observed facilitated rapid cell proliferation and differentiation.

Conclusions:

  • The developed printing strategy enables precise control over cellular orientation in biofabricated constructs.
  • This approach holds significant potential for advancing the engineering of functional tissues.