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Protein encapsulation: a new approach for improving the capability of small-molecule fluorogenic probes

Hai-Hao Han1,2, Adam C Sedgwick3,4, Ying Shang1

  • 1Key Laboratory for Advanced Materials, Joint International Research Laboratory of Precision Chemistry and Molecular Engineering, Feringa Nobel Prize Scientist Joint Research Center, School of Chemistry and Molecular Engineering, East China University of Science and Technology 130 Meilong Road Shanghai 200237 P. R. China xphe@ecust.edu.cn.

Chemical Science
|June 4, 2021
PubMed
Summary

We developed a novel protein-based strategy using human serum albumin (HSA) to improve the solubility and cell permeability of the Pinkment-OAc fluorescent probe. This hybrid enhances detection of peroxynitrite (ONOO-) in cells and in vivo.

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