Safety and tolerability of liquid amikacin in antibiotic-loaded bone cement - a case series

Area of Science:

• Orthopedics
• Infectious Diseases
• Pharmacology

Background:

• High-dose liquid antibiotics are rarely used in bone cement formulations.
• Periprosthetic joint infections (PJIs) are a significant complication following joint replacement surgery.
• Effective local antibiotic delivery is crucial for managing PJIs.

Purpose of the Study:

• To evaluate the feasibility and safety of incorporating high-dose liquid amikacin into bone cement.
• To assess the efficacy of amikacin-loaded bone cement in treating PJIs.
• To report on any adverse drug reactions associated with this method.

Main Methods:

• A case series approach was employed.
• Up to 16 mL of liquid amikacin (250 mg/mL) was incorporated into bone cement.
• The prepared bone cement was used in patients diagnosed with PJIs.

Main Results:

• Successful incorporation of high-dose liquid amikacin into bone cement was achieved.
• The treatment of PJIs using amikacin-loaded bone cement showed positive outcomes.
• No adverse drug reactions were definitively attributed to the use of liquid amikacin in bone cement.

Conclusions:

• High-dose liquid amikacin can be successfully incorporated into bone cement for PJI treatment.
• This method appears to be safe, with no observed adverse drug reactions.
• Amikacin-loaded bone cement represents a promising local antibiotic delivery strategy for PJIs.