The protective effect of early dietary fat consumption on Alzheimer's disease-related pathology and cognitive
Anna Amelianchik1, Jonathan Merkel1,2, Premkumar Palanisamy1
1Patricia and John Rosenwald Laboratory of Neurobiology and Genetics The Rockefeller University New York USA.
Introduction:
It has been suggested that obesity may influence Alzheimer's disease (AD) pathogenesis, yet the numerous publications on this topic have inconsistent results and conclusions.
Methods:
Our study examined the effect of varying the timing of high-fat diet (HFD) consumption on AD-related pathology and cognition in transgenic Tg6799 AD mice.
Results:
HFD feeding starting at or before 3 months of age, prior to severe AD pathology, had protective effects in AD mice: reduced extracellular amyloid beta (Aβ) deposition, decreased fibrinogen extravasation into the brain parenchyma, and improved cognitive function. However, delaying HFD consumption until 6 months of age, when AD pathology is ubiquitous, reduced these protective effects in AD mice.
Discussion:
Overall, we demonstrate that the timeline of HFD consumption may play an important role in how dietary fats affect AD pathogenesis and cognitive function.
