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Topiramate-induced angle closure glaucoma: Two unique case reports.

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Oral topiramate can cause secondary acute angle closure (AAC) even after discontinuation. Early detection of this ocular side effect is crucial for timely management and optimal patient outcomes.

Keywords:
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Area of Science:

  • Ophthalmology
  • Neurology

Background:

  • Oral topiramate is prescribed for seizure and migraine management.
  • Topiramate is known to cause ocular side effects.

Observation:

  • Two young patients developed bilateral ocular discomfort and blurring.
  • Secondary acute angle closure (AAC) with high intraocular pressure occurred after discontinuing topiramate.

Findings:

  • Discontinuation of oral topiramate led to secondary AAC in both patients.
  • Topical medications and multimodal imaging were used for management and monitoring.

Implications:

  • Recognizing topiramate's ocular side effects aids in early detection of secondary AAC.
  • Prompt topical treatment and imaging are key for managing this condition.