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Updated: Nov 3, 2025

A Microwave-Assisted Direct Heteroarylation of Ketones Using Transition Metal Catalysis
Published on: February 16, 2020
Visible-light-promoted α-methoxymethylation and aminomethylation of ketones with methanol as the C1 source
Jingya Yang1, Cai Liu1, Hongyan Zhou2
1College of Chemistry and Chemical Engineering, Northwest Normal University, Lanzhou 730070, China. yangjy@nwnu.edu.cn zhouhy@gsau.edu.cn.
Abstract:
Visible-light-promoted α-methoxymethylation and aminomethylation of ketones using methanol as a sustainable C1 source have been developed. With rose bengal as the photosensitizer and air as the green oxidant, the methoxymethylation reactions proceeded smoothly under visible light irradiation at ambient temperature. Additionally, a one-pot one-step α-aminomethylation of ketones was achieved by adding N-nucleophiles. Preliminary mechanism studies suggest that the reaction mainly proceeds via a radical pathway.
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