Related Experiment Video

Updated: Nov 3, 2025

Cutoff Value of Phase Angle by Bioelectrical Impedance Analysis at Admission as a Prognostic Factor in Patients with Acute Heart Failure
05:16

Cutoff Value of Phase Angle by Bioelectrical Impedance Analysis at Admission as a Prognostic Factor in Patients with Acute Heart Failure

Published on: June 10, 2025

334

Impact of heart failure severity on bone mineral density among older patients with heart failure

Yuji Kono1,2, Hideo Izawa3, Yoichiro Aoyagi2

  • 1Department of Rehabilitation, Fujita Health University Bantane Hospital, Nagoya, Japan.

Heart and Vessels
|June 4, 2021
PubMed

Insights

Older heart failure (HF) patients have lower bone mineral density (BMD). N-terminal pro B-type natriuretic peptide (NT-proBNP) is an independent factor related to BMD, suggesting fracture prevention strategies for HF management.

Area of Science:

  • Gerontology
  • Cardiology
  • Metabolic Bone Disease

Background:

  • Heart failure (HF) is prevalent in older adults.
  • Bone mineral density (BMD) loss is a concern in aging populations.
  • The relationship between HF and BMD requires further investigation.

Purpose of the Study:

  • To identify clinical factors associated with BMD in elderly patients diagnosed with HF.
  • To explore the correlation between HF severity markers and BMD.

Main Methods:

  • Seventy older patients (≥65 years) with acute HF were assessed before discharge.
  • Bone mineral density (BMD) of the femoral neck was measured using DEXA.
  • Physical function, echocardiographic, and laboratory data, including NT-proBNP, were collected and analyzed using regression models.

Main Results:

  • Bivariate analysis showed significant correlations between BMD and age, grip strength, walking speed, serum albumin, and NT-proBNP (P < 0.01).
  • Multiple regression analysis identified NT-proBNP as an independent predictor of BMD, even after adjusting for confounders.
  • No other clinical parameters showed independent association with BMD.

Conclusions:

  • NT-proBNP is independently associated with BMD in older heart failure patients.
  • These findings highlight the need to integrate bone fracture prevention into HF management programs for the elderly.

Keywords:
FrailtyHeart failureOsteoporosisRehabilitation

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