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Anti-COVID-19 measurements for hidradenitis suppurativa patients
Evangelos J Giamarellos-Bourboulis1,2, Vincenzo Bettoli1,3, Gregor B E Jemec1,4,5
1European Hidradenitis Suppurativa Foundation e.V., Dessau, Germany.
Insights
Patients with hidradenitis suppurativa (HS) appear to have a low incidence of COVID-19, and biological treatments do not seem to increase susceptibility. HS patients can be vaccinated against SARS-CoV-2, with those having metabolic syndrome prioritized.
Area of Science:
- Immunology
- Dermatology
- Infectious Diseases
Background:
- The incidence of COVID-19 in patients with inflammatory bowel and skin diseases on biologicals is low.
- Preliminary evidence suggests hidradenitis suppurativa (HS) does not increase COVID-19 susceptibility, and biological treatments may not negatively alter this risk.
- Some biological modifiers are being explored for COVID-19 management, potentially benefiting HS patients.
Framework:
- Consensus statement from European Hidradenitis Suppurativa Foundation e.V. experts on anti-COVID-19 measures for HS patients.
- Recommendations based on available scientific knowledge regarding COVID-19 and HS.
- Consideration of vaccination strategies for HS patients, including those with metabolic syndrome.
Implementation:
- HS patients are recommended for SARS-CoV-2 vaccination.
- Patients with metabolic syndrome and HS are identified as a high-risk group requiring timely vaccination.
- HS patients on adalimumab can receive non-living virus SARS-CoV-2 vaccines, with a potential for suboptimal immune response.
Implications:
- HS patients can be safely vaccinated against COVID-19.
- Metabolic syndrome in HS patients necessitates prioritized vaccination.
- Dermatologists should exercise discretion in managing biological treatments alongside vaccination.
Abstract:
The reported incidence of COVID-19 among cohorts of patients with inflammatory bowel and skin diseases under treatment with biologicals is low. Treatment may further modify disease severity as some biological modifiers, such as anakinra, are also proposed for the management of COVID-19 patients potentially providing HS patients with an advantage. The above preliminary evidence suggests that hidradenitis suppurativa (HS) does probably not provide an increased susceptibility for COVID-19 and that any susceptibility is unlikely to be modified negatively by treatment with biologicals. On the occasion of its 10th International Conference, experts of the European Hidradenitis Suppurativa Foundation e.V. have prepared a consensus statement regarding anti-COVID-19 measurements for HS patients. Based on the available knowledge, patients with HS may be vaccinated against SARS-CoV2 and patients affected by metabolic syndrome constitute a high-risk group for COVID-19 and should be vaccinated at the earliest convenient point in time. HS patients on treatment with adalimumab can be vaccinated with non-living virus anti-SARS-CoV2 vaccines. A possible suboptimal effect of the vaccine may be suspected but might not be expected universally. The management of the biological treatment in HS patients is at the discretion of the dermatologist / responsible physician.
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