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Related Experiment Video

Updated: Nov 3, 2025

Imaging and Quantification of the Area of Fast-Moving Microbubbles Using a High-Speed Camera and Image Analysis
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High Frame Rate Volumetric Imaging of Microbubbles Using a Sparse Array and Spatial Coherence Beamforming.

Luxi Wei, Geraldi Wahyulaksana, Bram Meijlink

    IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control
    |June 4, 2021
    PubMed
    Summary

    This study introduces an advanced ultrasound technique using sparse arrays and a spatial coherence beamformer to improve microvascular imaging. The method significantly reduces clutter, enhancing visualization of blood flow and microbubbles.

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    Area of Science:

    • Medical imaging
    • Ultrasound technology
    • Biomedical engineering

    Background:

    • Volumetric ultrasound imaging offers superior microvasculature visualization using microbubbles.
    • Sparse arrays reduce complexity but often suffer from high clutter, hindering imaging quality.
    • Wide beam transmissions for higher frame rates exacerbate clutter issues in sparse array systems.

    Purpose of the Study:

    • To demonstrate a method for achieving uniform transmission fields with sparse arrays.
    • To effectively suppress background clutter in volumetric ultrasound imaging.
    • To enhance the signal-to-background ratio for improved microvascular visualization.

    Main Methods:

    • Utilized a prototype sparse array probe and diverging wave transmission strategy.
    • Implemented a spatial coherence beamformer for clutter suppression.
    • Validated the approach using a tissue-mimicking phantom and a live chicken embryo model.

    Main Results:

    • Achieved a uniform transmission field with the sparse array probe.
    • Demonstrated significant background clutter suppression, improving signal to background ratio by 25 dB.
    • Successfully performed volumetric visualization of single microbubbles and vasculature mapping.

    Conclusions:

    • The developed method enables effective clutter reduction in sparse array volumetric ultrasound.
    • This technique enhances microvascular imaging, offering improved visualization of blood flow and microbubbles.
    • The approach shows promise for advanced diagnostic and research applications in biomedical imaging.