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Updated: Nov 3, 2025

Digital Planimetry for Assessing Wound Closure Kinetics in a Mouse Model
07:56

Digital Planimetry for Assessing Wound Closure Kinetics in a Mouse Model

Published on: January 10, 2025

850

Retraction

    Journal of Cellular Physiology
    |June 4, 2021
    PubMed

    Insights

    This study on kidney cancer cell activity has been retracted due to significant flaws and inconsistencies. The findings regarding circular RNA circC3P1, miR-21/PTEN axis, and PI3K/AKT/NF-kB pathways are considered invalid.

    Area of Science:

    • Oncology
    • Molecular Biology
    • Bioinformatics

    Context:

    • Kidney cancer progression involves complex molecular signaling pathways.
    • Circular RNAs (circRNAs) are emerging as critical regulators in various cancers.
    • The PI3K/AKT and NF-kB pathways are frequently dysregulated in renal cell carcinoma.

    Purpose:

    • To investigate the role of circular RNA circC3P1 in kidney cancer.
    • To elucidate the regulatory mechanism of circC3P1 involving miR-21 and the PTEN axis.
    • To determine the impact of circC3P1 on the PI3K/AKT and NF-kB signaling pathways in kidney cancer cells.

    Summary:

    • The article investigated how circC3P1 affects kidney cancer cell activity.
    • It proposed that circC3P1 regulates the miR-21/PTEN axis, impacting PI3K/AKT and NF-kB pathways.
    • However, the study has been retracted due to identified flaws and inconsistencies.

    Impact:

    • The retraction invalidates previous conclusions about circC3P1's role in kidney cancer.
    • This highlights the importance of rigorous validation in molecular oncology research.
    • Further research is needed to clarify the true function of circC3P1 in renal cell carcinoma.

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