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Bioavailability Enhancement: Drug Stability Enhancement and GI Retention

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Alternating Magnetic Field-Responsive Hybrid Gelatin Microgels for Controlled Drug Release

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Published on: February 13, 2016

Bioactive glass: A multifunctional delivery system.

Smriti Gupta¹, Shreyasi Majumdar¹, Sairam Krishnamurthy¹

¹Neurotherapeutics Laboratory, Department of Pharmaceutical Engineering and Technology, Indian Institute of Technology (Banaras Hindu University), Varanasi 221005, India.

Journal of Controlled Release : Official Journal of the Controlled Release Society

|June 4, 2021

Summary

This summary is machine-generated.

Bioactive glasses (BAGs) are versatile drug delivery systems, offering controlled release of therapeutics for conditions like osteoporosis and cancer. Further research is needed to bridge the gap between laboratory findings and clinical application.

Keywords:

Bioactive glass Dopant ions Drug-delivery systems Gene delivery vector Osteogenesis Phytopharmaceuticals

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Area of Science:

Biomaterials Science
Materials Chemistry
Drug Delivery Systems

Background:

Bioactive glasses (BAGs) have a 50-year history in orthopedic and dental applications.
Recent research has focused on BAGs as advanced delivery systems for diverse therapeutics, including ions, drugs, and macromolecules.
The unique properties of BAGs facilitate therapeutic molecule entrapment and controlled release kinetics.

Purpose of the Study:

To review the evolution of bioactive glasses from melt-quenched to mesoporous sol-gel formulations.
To summarize scientific advancements in using BAGs for delivering various therapeutic agents.
To identify challenges hindering the clinical translation of BAG-based therapies.

Main Methods:

Literature review of bioactive glass development and applications.
Analysis of therapeutic molecule loading and release mechanisms.
Evaluation of BAGs' biological activity and dissolution products.

Main Results:

BAGs offer tailorable controlled release kinetics for targeted delivery.
Dissolution products of BAGs exhibit beneficial biological activity in conditions like osteoporosis, cancer, infection, and inflammation.
Significant research has explored BAGs for delivering therapeutic ions, small molecules, and macromolecules.

Conclusions:

Bioactive glasses represent a promising platform for advanced drug delivery due to their tunable properties and therapeutic potential.
Addressing current research gaps is crucial for successful clinical translation of BAG-based therapies.
Future directions include optimizing BAG formulations for specific pathological conditions and enhancing their bench-to-bedside transition.