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Does COVID 19 generate a milieu for propagation of mucormycosis?

Deepak Pandiar1, N Siva Kumar2, Rahul Anand2

  • 1Department of Oral Pathology and Microbiology, Saveetha Dental College and Hospitals, Chennai, Tamil Nadu, India; Department of Oral Pathology and Microbiology, Postgraduate Institute of Dental Sciences, Rohtak, Haryana, India.

Medical Hypotheses
|June 4, 2021
PubMed

Insights

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes COVID-19, a multisystem disease. This study links virus-induced biochemical changes to mucormycosis, aiding early diagnosis and treatment.

Area of Science:

  • Infectious Diseases
  • Biochemistry
  • Mycology

Background:

  • COVID-19, caused by SARS-CoV-2, is a global health crisis impacting multiple organ systems.
  • The disease causes significant immunosuppression and biochemical alterations, including thromboembolism and cytokine storm.
  • An increased incidence of mucormycosis has been observed in COVID-19 patients.

Purpose of the Study:

  • To identify and correlate virus-mediated biochemical alterations in COVID-19 patients.
  • To establish these alterations as a potential environment for mucormycosis propagation.
  • To focus on the early diagnosis and treatment of mucormycosis in COVID-19 cases.

Main Methods:

  • Review of biochemical alterations reported in COVID-19 patients.
  • Correlation analysis between biochemical changes and mucormycosis incidence.
  • Literature review on mucormycosis in immunocompromised individuals.

Main Results:

  • COVID-19 induces a unique biochemical milieu, including elevated ferritin, lymphocytopenia, and thrombocytopenia.
  • These alterations create conditions conducive to the opportunistic infection, mucormycosis.
  • Equivocal data exists regarding neutrophil levels in COVID-19 patients.

Conclusions:

  • Virus-induced biochemical changes in COVID-19 patients foster mucormycosis development.
  • Early identification of these biochemical markers is crucial for predicting mucormycosis risk.
  • Prompt diagnosis and treatment of mucormycosis are essential for managing co-infected patients.

Keywords:
ACE2COVID 2019MucoralesMucormycosisSARS-CoV-2

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