Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Electron Transport Chain: Complex I and II01:46

Electron Transport Chain: Complex I and II

16.1K
The mitochondrial electron transport chain (ETC) is the main energy generation system in the eukaryotic cells. However, mitochondria also produce cytotoxic reactive oxygen species (ROS) due to the large electron flow during oxidative phosphorylation. While Complex I is one of the primary sources of superoxide radicals, ROS production by Complex II is uncommon and may only be observed in cancer cells with mutated complexes.
ROS generation is regulated and maintained at moderate levels necessary...
16.1K
mTOR Signaling and Cancer Progression03:03

mTOR Signaling and Cancer Progression

4.0K
The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...
4.0K
Replicative Cell Senescence02:15

Replicative Cell Senescence

4.0K
Replicative cell senescence is a property of cells that allows them to divide a finite number of times throughout the organism's lifespan while preventing excessive proliferation. Replicative senescence is associated with the gradual loss of the telomere — short, repetitive DNA sequences found at the end of the chromosomes. Telomeres are bound by a group of proteins to form a protective cap on the ends of chromosomes. Embryonic stem cells express telomerase — an enzyme that adds...
4.0K
Life Tables01:22

Life Tables

262
A life table is a statistical tool that summarizes the mortality and survival patterns of a population, providing detailed insights into the likelihood of survival or death across different age intervals within a cohort. By organizing data on survival probabilities and mortality rates, life tables offer a clear snapshot of population dynamics over time. They are extensively used in demography, public health, actuarial science, and ecology to analyze life expectancy, design health interventions,...
262

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Widening Racial Disparities During COVID-19 Telemedicine Transition: A Study of Child Mental Health Services at Two Large Children's Hospitals.

Journal of the American Academy of Child and Adolescent Psychiatry·2022
Same author

Safety and efficacy of ganaxolone in patients with CDKL5 deficiency disorder: results from the double-blind phase of a randomised, placebo-controlled, phase 3 trial.

The Lancet. Neurology·2022
Same author

Germline variants in tumor suppressor FBXW7 lead to impaired ubiquitination and a neurodevelopmental syndrome.

American journal of human genetics·2022
Same author

Interictal EEG and ECG for SUDEP Risk Assessment: A Retrospective Multicenter Cohort Study.

Frontiers in neurology·2022
Same author

Topographic divergence of atypical cortical asymmetry and atrophy patterns in temporal lobe epilepsy.

Brain : a journal of neurology·2022
Same author

Proteomic differences in hippocampus and cortex of sudden unexplained death in childhood.

Acta neuropathologica·2022
Same journal

Assessing cognition and quality of life in people with epilepsy: A feasibility study for mild and marked cognitive impairment.

Epilepsy & behavior : E&B·2026
Same journal

Validating the C-PHQ-9 suicide item against the C-NDDI-E for detecting suicidal ideation in Chinese adults with epilepsy.

Epilepsy & behavior : E&B·2026
Same journal

The IMPACT epilepsy Consortium: Exploring social drivers of health in epilepsy care to advance solution based initiatives.

Epilepsy & behavior : E&B·2026
Same journal

Surgical management of super-refractory status epilepticus (SRSE): a structured narrative review with considerations on refractory status epilepticus (RSE).

Epilepsy & behavior : E&B·2026
Same journal

Sex difference in the association of antiseizure medication load with cognitive decline in older people with epilepsy: A prospective study.

Epilepsy & behavior : E&B·2026
Same journal

Improving epilepsy knowledge, attitudes & practices among primary health care providers: findings from a pre-post intervention study in Central India.

Epilepsy & behavior : E&B·2026
See all related articles

Related Experiment Video

Updated: Nov 3, 2025

Utilizing Murine Inducible Telomerase Alleles in the Studies of Tissue Degeneration/Regeneration and Cancer
08:34

Utilizing Murine Inducible Telomerase Alleles in the Studies of Tissue Degeneration/Regeneration and Cancer

Published on: April 13, 2015

10.5K

Mortality in tuberous sclerosis complex.

Shridhar Parthasarathy1, Rajeshwari Mahalingam1, Jackie Melchiorre1

  • 1Saint Barnabas Institute of Neurology and Neurosurgery, United States.

Epilepsy & Behavior : E&B
|June 4, 2021
PubMed
Summary
This summary is machine-generated.

Tuberous Sclerosis Complex (TSC) mortality shows SUDEP as a leading cause of death, often in patients with intractable epilepsy. Early counseling on anti-seizure medication adherence and monitoring can help prevent SUDEP in TSC patients.

Keywords:
MortalitySudden unexpected death in epilepsy (SUDEP)Tuberous sclerosis complex

More Related Videos

Author Spotlight: Genetically Engineered Mouse Models and Pathological Characterization of Neurofibromatosis Type 1 Associated Tumors
08:57

Author Spotlight: Genetically Engineered Mouse Models and Pathological Characterization of Neurofibromatosis Type 1 Associated Tumors

Published on: May 17, 2024

2.2K
Author Spotlight: Unveiling Transmembrane Protein Family-Related Markers in Gastric Cancer and Implications for Targeted Therapies
07:47

Author Spotlight: Unveiling Transmembrane Protein Family-Related Markers in Gastric Cancer and Implications for Targeted Therapies

Published on: September 15, 2023

1.9K

Related Experiment Videos

Last Updated: Nov 3, 2025

Utilizing Murine Inducible Telomerase Alleles in the Studies of Tissue Degeneration/Regeneration and Cancer
08:34

Utilizing Murine Inducible Telomerase Alleles in the Studies of Tissue Degeneration/Regeneration and Cancer

Published on: April 13, 2015

10.5K
Author Spotlight: Genetically Engineered Mouse Models and Pathological Characterization of Neurofibromatosis Type 1 Associated Tumors
08:57

Author Spotlight: Genetically Engineered Mouse Models and Pathological Characterization of Neurofibromatosis Type 1 Associated Tumors

Published on: May 17, 2024

2.2K
Author Spotlight: Unveiling Transmembrane Protein Family-Related Markers in Gastric Cancer and Implications for Targeted Therapies
07:47

Author Spotlight: Unveiling Transmembrane Protein Family-Related Markers in Gastric Cancer and Implications for Targeted Therapies

Published on: September 15, 2023

1.9K

Area of Science:

  • Neurology
  • Genetics
  • Clinical Research

Background:

  • Tuberous Sclerosis Complex (TSC) is a genetic disorder with significant morbidity and mortality.
  • Understanding mortality patterns in TSC is crucial for patient care and management.
  • Sudden Unexpected Death in Epilepsy (SUDEP) is a recognized risk in individuals with epilepsy, including those with TSC.

Purpose of the Study:

  • To investigate the causes and patterns of mortality in a large cohort of patients with Tuberous Sclerosis Complex (TSC).
  • To identify specific risk factors associated with mortality, particularly Sudden Unexpected Death in Epilepsy (SUDEP).

Main Methods:

  • Analysis of data from 2233 patients in the Tuberous Sclerosis Alliance Natural History Database.
  • Review of mortality data for 31 deceased patients, with detailed examination of causes of death.
  • Specific analysis of characteristics of patients who experienced SUDEP.

Main Results:

  • The mean age of death among 31 TSC decedents was 29 years.
  • Sudden Unexpected Death in Epilepsy (SUDEP) was the most frequent cause of death (35.5%), with a mean age of epilepsy onset at 7 months.
  • Respiratory conditions and tumors were also significant causes of mortality in the TSC cohort.

Conclusions:

  • SUDEP is a primary concern in Tuberous Sclerosis Complex (TSC) mortality, often occurring in patients with long-standing or intractable epilepsy.
  • Counseling patients and families on anti-seizure medication (ASM) adherence, lifestyle modifications, and potential use of nocturnal supervision or seizure detection devices is recommended to mitigate SUDEP risk.
  • Further research into SUDEP prevention strategies in TSC is warranted.