Direct and indirect parameter imaging methods for dynamic PET

The method of reconstructing parametric images from dynamic positron emission tomography (PET) data with the linear Patlak model has been widely used in scientific research and clinical practice. Whether for direct or indirect image reconstruction, researchers have deeply investigated the associated methods and effects. Among the existing methods, the traditional maximum likelihood expectation maximization (MLEM) reconstruction algorithm is fast but produces a substantial amount of noise. If the parameter images obtained by the MLEM algorithm are postfiltered, a large amount of image edge information is lost. Additionally, although the kernel method has a better noise reduction effect, its calculation costs are very high due to the complexity of the algorithm. Therefore, to obtain parametric images with a high signal-to-noise ratio (SNR) and good retention of detailed information, here, we use guided kernel means (GKM) and dynamic PET image information to conduct guided filtering and perform parametric image reconstruction. We apply this method to direct and indirect reconstruction, and through computer simulations, we show that our proposed method has higher identifiability and a greater SNR than conventional direct and indirect reconstruction methods. We also show that our method produces better images with direct than with indirect reconstruction.