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Primary biliary non-Hodgkin's lymphoma: A case report
Jiamei Wu1, Yin Zhou1, Qingshu Li2
1Department of Radiology.
Medicine
|June 4, 2021
Summary
Primary biliary non-Hodgkin's lymphoma (PBNHL) is a rare condition often misdiagnosed as cholangiocarcinoma. Early consideration of PBNHL is crucial for patients with Epstein-Barr virus infection and suggestive imaging findings.
Area of Science:
- Oncology
- Pathology
- Radiology
Background:
- Primary biliary non-Hodgkin's lymphoma (PBNHL) is an exceptionally rare malignancy, with limited reported cases.
- PBNHL represents a small fraction of extranodal and overall non-Hodgkin's lymphoma incidence.
Observation:
- A 59-year-old female presented with jaundice, weight loss, and Epstein-Barr virus infection.
- Initial imaging revealed diffuse bile duct wall thickening and stenosis, mimicking hilar cholangiocarcinoma.
- Postoperative pathology confirmed PBNHL, despite initial diagnostic challenges.
Findings:
- Despite surgical intervention, the patient experienced disease progression with new liver mass formation.
- CT and MRI showed initial improvement in bile duct stenosis followed by new lesion development.
Implications:
- Accurate preoperative diagnosis of PBNHL is challenging due to its rarity and overlapping features with cholangiocarcinoma.
- PBNHL should be included in the differential diagnosis for patients presenting with Epstein-Barr virus infection and characteristic biliary imaging findings.
