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Blind liver biopsy: a 17-year experience
Nafiye Urganci1, Tugce Kurtaraner2, Derya Kalyoncu3
1SBU Sisli Etfal Training and Research Hospital, Division of Pediatric Gastroenterology. Istanbul, Turkey.
Summary
Percutaneous liver biopsy is a safe and effective diagnostic tool for pediatric liver diseases. This study evaluated clinical indications and histopathological outcomes in 516 children, confirming its safety in childhood liver disease diagnosis.
Area of Science:
- Pediatric Hepatology
- Diagnostic Procedures
- Histopathology
Background:
- Liver biopsy remains the gold standard for evaluating liver inflammation, necrosis, and fibrosis.
- Accurate diagnosis is crucial for effective management of pediatric liver conditions.
Purpose of the Study:
- To assess the clinical indications for percutaneous liver biopsy in children.
- To evaluate the histopathological findings and safety of percutaneous liver biopsy in pediatric patients.
Main Methods:
- Retrospective evaluation of 516 children who underwent blind liver biopsy.
- Analysis of clinical indications, histopathological results, and complication rates.
Main Results:
- The most common indications included chronic active hepatitis B (50%), neonatal cholestasis (14%), and autoimmune hepatitis (7.7%).
- Major complications occurred in 0.19% of cases, with minor complications like pain reported in 13.5%.
Conclusions:
- Blind percutaneous liver biopsy is a safe and valuable diagnostic method for various liver diseases in childhood.
- The procedure provides essential histopathological information for guiding treatment decisions.
