Different sized particles associated with all-cause and cause-specific emergency ambulance calls: A multicity...

Compared with mortality and hospital admission, emergency ambulance calls (EACs) could be a more accurate outcome indicator to reflect the health effects of short-term air pollution exposure. However, such studies have been scarce, especially on a multicity scale in China.

We estimated the associations of different diameter particles [i.e., inhalable particulate matter (PM₁₀), coarse particulate matter (PM_c), and fine particulate matter (PM_2.5)] with EACs for all-cause, cardiovascular, and respiratory diseases in seven Chinese cities. We collected data on EACs and air pollution from 2014 to 2019. We used generalized additive models and random-effects meta-analysis to examine the city-specific and overall associations. Stratified analyses were conducted to examine the effect modifications of gender, age, and season.

Significant associations of PM₁₀ and PM_2.5 with EACs were observed, while the PM_c associations were positive but not statistically significant in most analyses. Specifically, each 10 μg/m³ increase in 2-day moving average concentration of PM₁₀ was associated with a 0.25% [95% confidence interval (CI): 0.04%, 0.47%] increase in all-cause EACs, 0.13% (95% CI: -0.01%, 0.26%) in cardiovascular EACs, and 0.35% (95% CI: 0.04%, 0.66%) in respiratory EACs. The corresponding increases in daily EACs for PM_2.5 were 0.30% (95% CI, 0.03%, 0.57%), 0.13% (95% CI, -0.07%, 0.33%), and 0.46% (95% CI, 0.01%, 0.92%). Season of the year also modifies the association between particulate matter pollution and EACs.

Short-term exposure to PM₁₀ and PM_2.5 were positively associated with daily all-cause and respiratory-related EACs. The associations were stronger during warm season than cold season. Our findings suggest that the most harmful fraction of particulate matter pollution is PM_2.5, which has important implications for current air quality guidelines and regulations in China.