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Fluorescence Lifetime Macro Imager for Biomedical Applications
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Fluorescence optical imaging: ready for prime time?

Sarah Ohrndorf1, Anne-Marie Glimm1, Mads Ammitzbøll-Danielsen2,3

  • 1Department of Rheumatology and Clinical Immunology, Charité - Universitätsmedizin Berlin, Campus Mitte, Humboldt - Universität zu Berlin, Freie Universität Berlin, Berlin, Germany.

RMD Open
|June 5, 2021
PubMed
Summary
This summary is machine-generated.

Fluorescence optical imaging (FOI) effectively detects joint inflammation and microcirculation impairments in conditions like psoriatic arthritis. This technique shows high agreement with MRI and ultrasound, offering a valuable diagnostic tool in rheumatology.

Keywords:
arthritisinflammationjuvenilepsoriaticrheumatoidsynovitis

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Area of Science:

  • Rheumatology
  • Medical Imaging
  • Microcirculation Studies

Background:

  • Fluorescence optical imaging (FOI), utilizing indocyanine green, is an approved clinical technique since 2009.
  • FOI can visualize impaired microcirculation due to inflammation in the hands.
  • Previous studies have explored FOI for detecting joint inflammation.

Purpose of the Study:

  • To evaluate the efficacy of FOI in detecting joint inflammation and microcirculation abnormalities.
  • To compare FOI with established imaging modalities like MRI and MSUS.
  • To assess the potential of FOI in diagnosing early undifferentiated arthritis and monitoring vascular changes in systemic sclerosis.

Main Methods:

  • Comparison of FOI with clinical examination, MRI, and musculoskeletal ultrasound (MSUS) with power Doppler.
  • Analysis of characteristic enhancements in skin and nails observed with FOI in psoriatic arthritis (PsA).
  • Investigation of FOI for visualizing disturbed microcirculation in systemic sclerosis (SSc) patients.

Main Results:

  • FOI demonstrated good agreement (>80%) with clinical examination, MRI, and MSUS in identifying inflammatory joint diseases.
  • Characteristic skin and nail enhancements were observed in PsA, suggesting diagnostic utility.
  • FOI successfully visualized microcirculatory disturbances in the hands and fingers of SSc patients.

Conclusions:

  • FOI is a valuable imaging tool for rheumatology, particularly for assessing joint inflammation and microvascular changes.
  • The technique shows promise in the diagnosis of early arthritis and monitoring vasculopathies.
  • FOI serves as a useful alternative imaging modality when MSUS and MRI are less accessible.