Related Experiment Video

Updated: Nov 3, 2025

MicroRNA Amplification and Recognition through Locked-nucleic-acid In situ Hybridization as A Novel Detection and Quantification Method
09:06

MicroRNA Amplification and Recognition through Locked-nucleic-acid In situ Hybridization as A Novel Detection and Quantification Method

Published on: October 7, 2025

84

Cancer-associated miRNAs and their therapeutic potential

Jun Inoue1, Johji Inazawa2,3

  • 1Department of Molecular Cytogenetics, Medical Research Institute, Tokyo Medical and Dental University (TMDU), Tokyo, Japan. jun.cgen@mri.tmd.ac.jp.

Journal of Human Genetics
|June 5, 2021
PubMed

Insights

MicroRNAs (miRNAs) regulate gene expression and are implicated in cancer. miRNA therapeutics, targeting oncogenic or tumor-suppressive miRNAs, offer a promising new treatment for advanced cancers.

Area of Science:

  • Molecular Biology
  • Genetics
  • Oncology

Background:

  • MicroRNAs (miRNAs) are small non-coding RNAs that regulate gene expression.
  • Aberrant miRNA expression is linked to cancer development and progression.
  • Targeting cancer-associated miRNAs presents a novel therapeutic strategy.

Purpose of the Study:

  • To review cancer-associated miRNAs and their roles in various cancer pathologies.
  • To summarize the clinical applications of miRNA therapeutics for cancer treatment.

Main Methods:

  • Literature review of studies on cancer-associated miRNAs.
  • Analysis of miRNA involvement in cancer development and progression.
  • Examination of current miRNA therapeutic strategies, including anti-miRs and miRNA mimics.

Main Results:

  • Identified specific miRNAs abnormally expressed in various cancers.
  • Highlighted the potential of inhibiting oncogenic miRNAs (OncomiRs) and restoring tumor suppressive miRNAs (TS-miRs).
  • Demonstrated the development of miRNA-based therapeutics.

Conclusions:

  • miRNA-based therapeutics hold significant promise for treating advanced cancers.
  • Targeting specific miRNAs offers a precise approach to cancer therapy.
  • Further clinical applications of miRNA therapeutics are anticipated.

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