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Lymphocyte Isolation from Human Skin for Phenotypic Analysis and Ex Vivo Cell Culture

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Psoriasis: Embarking a dynamic shift in the skin microbiota.

Mrinal Gupta¹, Jeffrey M Weinberg², Paul S Yamauchi^3,4

¹DNB Dermatology Consultant Dermatologist, Treatwell Skin Centre, Jammu, India.

Journal of Cosmetic Dermatology

|June 5, 2021

Summary

The skin and gut microbiome composition is altered in psoriasis patients, potentially contributing to disease development. Further research explores the pathogenic mechanisms linking microbiota to psoriasis exacerbation.

Keywords:

microbiome microbiota psoriasis

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Area of Science:

Dermatology
Microbiology
Immunology

Background:

Psoriasis pathogenesis is increasingly linked to the microbiome.
Alterations in skin flora are observed between healthy individuals and psoriatic patients.
Specific microbes like *Streptococci*, *Malassezia*, *Staphylococcus aureus*, and *Candida albicans* may influence psoriasis exacerbation.

Purpose of the Study:

To review and evaluate the pathogenic mechanisms connecting the microbiota to psoriasis.
To synthesize current understanding of the role of cutaneous and gut microbiome in psoriasis.

Main Methods:

Comprehensive literature search of peer-reviewed articles.
Databases searched include MEDLINE and PubMed from January 1990 to March 2021.
Included clinical trials, original reports, and scientific reviews.

Main Results:

Evidence suggests a significant association between microbiome composition and psoriasis.
Specific microbial colonization may trigger or worsen psoriatic conditions.
Both skin and gut microbiomes are implicated in disease development.

Conclusions:

The microbiome plays a crucial role in the pathogenesis of psoriasis.
Understanding these microbial links can inform future therapeutic strategies.
Further investigation into microbiota-targeted interventions for psoriasis is warranted.