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Diabetes following acute pancreatitis
Phil A Hart1, David Bradley2, Darwin L Conwell1
1Division of Gastroenterology, Hepatology, and Nutrition, The Ohio State University Wexner Medical Center, Columbus, OH, USA.
The Lancet. Gastroenterology & Hepatology
|June 5, 2021
Summary
Type 3c diabetes, or pancreatogenic diabetes, can develop after acute pancreatitis. Its causes are complex and multifactorial, requiring further research for effective management strategies.
Area of Science:
- Endocrinology
- Gastroenterology
- Metabolic Disorders
Background:
- Diabetes mellitus is characterized by hyperglycemia.
- Pancreatogenic diabetes (type 3c) arises from pancreatic exocrine dysfunction.
- Acute pancreatitis is a known precursor to type 3c diabetes.
Purpose of the Study:
- To review the epidemiology of diabetes following acute pancreatitis.
- To elucidate the pathophysiology of acute pancreatitis-related diabetes.
- To discuss current management strategies and identify knowledge gaps.
Main Methods:
- Literature review of studies on acute pancreatitis and subsequent diabetes.
- Analysis of epidemiological data.
- Synthesis of current understanding of pathophysiology and clinical management.
Main Results:
- Diabetes is a recognized complication across all severities of acute pancreatitis.
- The pathophysiology is multifactorial and not fully understood.
- Management requires tailored approaches considering pancreatic function.
Conclusions:
- Diabetes following acute pancreatitis (type 3c) is a significant clinical issue.
- Further research is needed to clarify pathophysiology and optimize treatment.
- Integrated management strategies are crucial for affected patients.
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