Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Synthesis and Regulation of Thyroid Hormones01:20

Synthesis and Regulation of Thyroid Hormones

6.0K
Low blood levels of the thyroid hormones — triiodothyronine (T3) and thyroxine (T4) — signal the hypothalamus to release the thyrotropin-releasing hormone (TRH). TRH then reaches the pituitary gland and stimulates the release of thyroid-stimulating hormone(TSH) into the bloodstream.
Upon reaching the thyroid gland, TSH stimulates the follicular cells' active uptake of iodide ions from the blood. The ions diffuse to the apical surface of the cells and are oxidized to iodine. The...
6.0K
Functions of Thyroid Hormones01:18

Functions of Thyroid Hormones

3.9K
The thyroid hormone (TH) plays a pivotal role in the intricate orchestration of physiological processes, exerting profound effects on development, metabolism, and homeostasis throughout different life stages.
TH is indispensable for the normal development and maturation of the skeletal, muscular, and nervous systems during fetal and childhood growth. It facilitates bone mineral turnover and regulates protein synthesis in developing tissues, contributing significantly to overall growth and...
3.9K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Decoding the human CD4<sup>+</sup> T cell epitope repertoire for Lassa fever virus reveals T cell-based pan-mammarenavirus vaccine candidates.

Cell reports. Medicine·2026
Same author

Graded BMP signals modulate yellow and red color in fishes, impacting adult pigment patterns and conspecific shoaling behavior.

Current biology : CB·2026
Same author

Cell type diversification and phenotype convergence underlying white fin-ornamentation of cyprinid fishes.

Proceedings of the National Academy of Sciences of the United States of America·2026
Same author

Cell-cell communication as underlying principle governing color pattern formation in teleost fishes.

Nature communications·2026
Same author

Graded BMP signals modulate yellow and red color in fishes impacting adult pigment pattern and behavior.

bioRxiv : the preprint server for biology·2025
Same author

Primordial germ cell specification and early developmental cell states in Pacific oyster.

BMC genomics·2025

Related Experiment Video

Updated: Nov 3, 2025

Analyzing Craniofacial Morphogenesis in Zebrafish Using 4D Confocal Microscopy
09:16

Analyzing Craniofacial Morphogenesis in Zebrafish Using 4D Confocal Microscopy

Published on: January 30, 2014

11.3K

Thyroid hormone regulates abrupt skin morphogenesis during zebrafish postembryonic development.

Andrew J Aman1, Margaret Kim1, Lauren M Saunders2

  • 1Department of Biology, University of Virginia, Charlottesville, VA, 22903, USA.

Developmental Biology
|June 5, 2021
PubMed
Summary
This summary is machine-generated.

Thyroid hormone regulates zebrafish skin development by interacting with nuclear receptors, ensuring correctly proportioned scales during post-embryonic growth. This research clarifies hormone actions on skin development.

Keywords:
GrowthPatterningPostembryonic developmentScalesSquamationThyroid hormoneZebrafish

More Related Videos

Reverse Genetic Approach to Identify Regulators of Pigmentation using Zebrafish
07:16

Reverse Genetic Approach to Identify Regulators of Pigmentation using Zebrafish

Published on: March 1, 2022

2.5K
Microbead Implantation in the Zebrafish Embryo
05:54

Microbead Implantation in the Zebrafish Embryo

Published on: July 30, 2015

11.8K

Related Experiment Videos

Last Updated: Nov 3, 2025

Analyzing Craniofacial Morphogenesis in Zebrafish Using 4D Confocal Microscopy
09:16

Analyzing Craniofacial Morphogenesis in Zebrafish Using 4D Confocal Microscopy

Published on: January 30, 2014

11.3K
Reverse Genetic Approach to Identify Regulators of Pigmentation using Zebrafish
07:16

Reverse Genetic Approach to Identify Regulators of Pigmentation using Zebrafish

Published on: March 1, 2022

2.5K
Microbead Implantation in the Zebrafish Embryo
05:54

Microbead Implantation in the Zebrafish Embryo

Published on: July 30, 2015

11.8K

Area of Science:

  • Developmental biology
  • Endocrinology
  • Dermatology

Background:

  • Thyroid hormone is crucial for vertebrate development, with skin being a significant target organ.
  • Mechanisms of thyroid dysfunction's impact on skin pathologies are not fully understood.
  • Zebrafish offer a transparent skin model for studying vertebrate skin development.

Purpose of the Study:

  • To investigate the role of thyroid hormone in post-embryonic zebrafish skin development.
  • To elucidate the molecular mechanisms involving nuclear hormone receptors in skin appendage formation.
  • To understand how thyroid hormone integrates skin development with overall body growth.

Main Methods:

  • Utilizing the zebrafish as a model organism with transparent skin.
  • Observing scale emergence from dermal papillae during post-embryonic development.
  • Investigating the interaction of thyroid hormone with nuclear hormone receptors in vivo.

Main Results:

  • Thyroid hormone significantly regulates the rate of post-embryonic dermal development in zebrafish.
  • This hormonal regulation ensures the formation of a well-ordered array of correctly proportioned scales.
  • Thyroid hormone's interaction with nuclear receptors was identified as a key mechanism.

Conclusions:

  • Thyroid hormone plays a vital role in coordinating skin development with body growth.
  • This study provides in-vivo evidence for thyroid hormone's regulation of multiple dermal development aspects.
  • Findings enhance understanding of thyroid hormone's actions on skin and its implications for pathologies.