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Semi-Targeted Ultra-High-Performance Chromatography Coupled to Mass Spectrometry Analysis of Phenolic Metabolites in Plasma of Elderly Adults
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Bioactivity, bioavailability, and gut microbiota transformations of dietary phenolic compounds: implications for

Paula R Augusti1, Greicy M M Conterato2, Cristiane C Denardin3

  • 1Instituto de Ciência e Tecnologia de Alimentos, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, RS, Brazil.

The Journal of Nutritional Biochemistry
|June 5, 2021
PubMed

Insights

Phenolic compounds (PC) show promise as a dietary supplement to mitigate COVID-19 by offering antioxidant, antiviral, and anti-inflammatory benefits. Further research explores their digestion, bioavailability, and safety for therapeutic use.

Area of Science:

  • Nutritional Science
  • Pharmacology
  • Microbiology

Background:

  • The COVID-19 pandemic necessitates novel therapeutic strategies due to the lack of effective treatments.
  • Dietary phenolic compounds (PC) are being investigated for their potential role in managing COVID-19.
  • Understanding the mechanisms of PC is crucial for their application in disease mitigation.

Purpose of the Study:

  • To review the scientific data on the bioactivity of phenolic compounds (PC) relevant to COVID-19.
  • To investigate the antioxidant, antiviral, anti-inflammatory, and immunomodulatory effects of dietary PC.
  • To assess the impact of digestion, bioavailability, and gut microbiota on PC's efficacy and discuss safety.

Main Methods:

  • Literature review of scientific data on phenolic compounds and COVID-19.
  • Analysis of antioxidant, antiviral, anti-inflammatory, and immunomodulatory properties of PC.
  • Examination of PC bioavailability, biotransformation by gut microbiota, and drug interactions.

Main Results:

  • Phenolic compounds exhibit significant antioxidant, antiviral, anti-inflammatory, and immunomodulatory activities.
  • The bioavailability and gut microbiota biotransformation of PC influence their therapeutic potential against COVID-19.
  • Safety considerations and potential drug interactions of PC require careful evaluation for clinical application.

Conclusions:

  • Dietary phenolic compounds represent a promising adjunct approach for COVID-19 management.
  • Further research into the digestive fate and interactions of PC is warranted to optimize their therapeutic use.
  • PC hold potential as a safe and effective nutritional or therapeutic strategy against COVID-19.
Keywords:
CoronavirusCurcuminImmune systemInflammationOxidative stressQuercetinResveratrolSARS-CoV-2

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