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Neurophysiological evaluation of visual function in iRBD: potential role in stratifying RBD conversion risk
Michele Terzaghi1, Alfredo Romani2, Marina Ranzani2
1Unit of Sleep Medicine and Epilepsy, IRCCS Mondino Foundation, Pavia, Italy; Department of Brain and Behavioral Sciences, University of Pavia, Pavia, Italy.
Sleep Medicine
|June 5, 2021
Summary
Visual Evoked Potentials (VEP) alterations in idiopathic REM sleep Behavior Disorder (iRBD) can predict neurodegenerative disease. Abnormal VEP patterns in iRBD patients may indicate synucleinopathy risk.
Area of Science:
- Neuroscience
- Ophthalmology
- Neurology
Background:
- Idiopathic REM sleep Behavior Disorder (iRBD) is a prodromal sign for synucleinopathies.
- Neurophysiological markers are needed to predict neurodegenerative disease conversion in iRBD patients.
Purpose of the Study:
- To evaluate visual function neurophysiology in iRBD patients.
- To identify visual evoked potential (VEP) alterations as markers and predictors of neurodegenerative disorders.
Main Methods:
- Longitudinal follow-up of 46 iRBD patients over 8.4 years.
- Comparison of baseline VEP parameters (pattern, color, motion) in iRBD patients with early (ePD) and advanced (aPD) Parkinson's Disease.
- Analysis of VEP parameters in iRBD converters versus non-converters.
Main Results:
- Pattern VEP (VEPp) P100 latencies were significantly longer in iRBD, ePD, and aPD groups compared to controls.
- VEPp latencies were longer in aPD than iRBD, with iRBD not differing from ePD.
- Abnormal VEPp findings and longer P100 latencies predicted conversion to neurodegenerative disorders in iRBD patients.
Conclusions:
- Abnormal pattern VEP (VEPp) in iRBD patients may signal synucleinopathy.
- VEPp abnormalities can help stratify phenoconversion risk in iRBD.
- Chromatic and motion VEPs did not show significant differences.
